CAS: 386715-33-9; 5-(Chloromethyl)-2-(Trifluoromethyl)Pyridine

相似化合物

1620-71-9 108274-33-5 1060814-58-5

上下游产品

6-trifluoromethylnicotinic acid methyl 6-(trifluoromethyl)pyridine-3-carboxylate 6-(trifluoromethyl)pyridin-3-ylmethanol 6-(trifluoromethyl)pyridine-3-carbaldehyde7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one 8-bromo-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 3-[6-chloro-2-methyl-1-(6-trifluoromethyl-pyridin-3-ylmethyl)-1H-indol-3-ylsulfanyl]-benzoic acid methyl ester 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile

6-三氟甲基-3-吡啶甲醇置于氯化亚砜体系中,用 二氯甲烷 用作溶剂,化学反应生成2-三氟甲基-5-氯甲基吡啶
参考文献:通往印za烷的模块化路线
标题:通往印za烷的模块化路线
摘要:描述了基于收敛性自由基的氮杂茚满路线,其依赖于各种取代的s-(吡啶甲基)-O-乙基二硫代碳酸酯(黄原酸酯)的退化加成转移至功能性烯烃,然后自由基环化至吡啶环上,所述吡啶环通过用三氟乙酸质子化而活化.在一种情况下,一个富于装饰环庚并[ B ]吡啶,可以迅速地通过允许第一加合物组装ñ苯基马来经历除了ñ之前环化-Allylphthalimide.
Doi:10.1021/acs.Orglett.7B01772

专利信息

专利号:US-9708278-B2
优先权日:2013-11-27
标 题 :Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; STAUFFER SHAUN R; PANARESE JOSEPH D
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to N-substituted 3,4-dihydro-benzo[£][1,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.