CAS: 5497-67-6; 2,2-Dimethylpent-4-Enal

相似化合物

16386-93-9 86549-27-1 2978-30-5

上下游产品

isobutyraldehyde diallyl acetal allyl alcohol isobutyraldehyde cyclohexyl-(2,2-dimethyl-pent-4-enylidene)-amine dimethylvaleraldehyde 2,2-dimethylpentanol 2,2-dimethylpent-4-en-1-ol 2,2-dimethyl-1-phenyl-pent-4-en-1-ol

Tert-Butyl-[2,2-Dimethyl-Pent-4-En-(E)-Ylidene]-Amine置于草酸体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 2.0H,以88%的收率获得产物2,2-二甲基-4-戊烯醛
参考文献:Synthesis Of 3-Alkenylamines,4-Alkenylamines And 3-Allenylamines Via A Transamination Procedure
标题:Synthesis Of 3-Alkenylamines,4-Alkenylamines And 3-Allenylamines Via A Transamination Procedure
摘要:3-Alkenylamines,4-Alkenylamines And 3-Allenylamines Were Synthesized Conveniently By Potassium T-Butoxide Induced Transamination Of Alpha-Vinylaldimines,Alpha-Allylaldimines Or Alpha-Allenylaldimines Followed By Hydrolysis With Aqueous Oxalic Acid. (C) 1997 Elsevier Science Ltd.
DOI:10.1016/s0040-4020(97)00688-1

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-9856276-B2
优先权日:2010-01-26
标 题:Compounds useful in the synthesis of halichondrin B analogs
发明人：ENDO ATSUSHI; CHASE CHARLES E; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III):

专利号:US-8796454-B2
优先权日:2012-05-04
标 题 :Synthesis of [2.2.2]-diazabicyclic ring systems
发明人：SCHEERER JONATHAN R
权利人:COLLEGE WILLIAM & MARY
摘要:Herein we describe compositions and methods for the synthesis of [2.2.2]-diazabicyclic structures comprising a domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition. Excellent diastereofacial control during the cycloaddition is enforced with a removable chiral phenyl aminal diketopiperazine substituent. The reaction sequence rapidly generates molecular complexity and is competent with both enolizable and non-enolizable aldehyde substrates. This method provides an efficient route to [2.2.2]-diazabicyclic structures, common to bioactive prenylated indole alkaloids such as the brevianamides and stephacidins.