CAS: 570-08-1; Diethyl 2-Acetylmalonate

相似化合物

21633-78-3 133-13-1 603-69-0

上下游产品

diethyl 2-(1-ethoxyethylidene)malonate chloroformic acid ethyl ester sodium ethyl acetylacetate enolate diethyl ether(1-acetoxy-ethylidene)-malonic acid diethyl ester 2-[(bis-ethoxycarbonyl-methylene)-hydrazino]-benzoic acid 2-(1,3-bis-ethoxycarbonyl-2-oxo-propylidenehydrazino)-benzoic acid 2-ethoxycarbonylmethyl-2-hydroxy-4-oxo-6-phenyl-cyclohexane-1,3,5-tricarboxylic acid triethyl ester

2-(1-乙氧基亚乙基)丙二酸二乙酯置于盐酸体系中,化学反应生成 乙酰基丙二酸二乙酯
参考文献:Barnes; Kundiger; Mcelvain,Journal Of The American Chemical Society,1940,Vol. 62,P. 1285
标题:Barnes; Kundiger; Mcelvain,Journal Of The American Chemical Society,1940,Vol. 62,P. 1285

专利信息

专利号:US-9938228-B2
优先权日:2014-09-09
标题:Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
发明人：JIN XIANGLE; DONG WEITONG; FU YAN; LU JUN; XIE LE; XU WEI; YANG JINSONG; ZHU QIAN
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

专利号:US-5064953-A
优先权日:1983-12-29
标 题:Intermediates cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:US-5134231-A
优先权日:1985-12-28
标题 :3(1-hydoxyethyl)azetidinone compounds and their production
发明人：SUNAGAWA MAKOTO; NOZAKI YOSHIHITO; SASAKI AKIRA; MATSUMURA HARUKI
权利人:SUMITOMO PHARMA
摘要:An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R 1 is a hydrogen atom or a protecting group for carboxyl, R 2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula: ##STR2## (wherein R 3 and R 4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula: n n --CH.sub.2 SR.sub.5 n n (wherein R 5 is an aryl group or an ar(lower)alkyl group), which is a useful intermediate in the synthesis of 1-alkylcarbapenem compounds.

专利号:US-6486323-B1
优先权日:1998-09-30
标 题:Process for producing optically active tropinonemonocarboxylic acid derivative
发明人：NODE MANABU; NAKAMURA SOICHI; NAKAMURA DAISAKU
权利人:NIHON MEDIPHYSICS CO LTD
摘要:An optically active tropinonemonocarboxylic acid ester derivative useful as an intermediate for synthesis of optically active tropane derivatives was obtained by reacting succindialdehyde with an organic amine and acetonedicarboxylic acid ester to obtain a tropinonedicarboxylic acid ester derivative, and then subjecting this derivative to enzyme-catalyzed asymmetric dealkoxy-carbonylation. Since anhydroecgonine methyl ester derived from the optically active tropinone-monocarboxylic acid ester derivative by reduction and dehydration had the same direction of optical rotation as in the case of anhydroecgonine methyl ester obtained from natural cocaine, it was proved that the obtained optically active tropinonemonocarboxylic acid ester derivative had the same absolute configuration as that of natural cocaine. The yield of the optically active tropinonemonocarboxylic acid ester derivative from the asymmetric dealkoxycarbonylation was 30 to 50 mol %, and its optical purity was 70 to 97% ee. In addition, it was found that a crystalline optically active anhydroecgonine carboxylic acid ester derivative can be obtained by reducing and then dehydrating the optically active tropinonemonocarboxylic acid ester derivative and that its optical purity can easily be increased by recrystallization.

专利号:US-4888332-A
优先权日:1983-12-29
标 题 :Cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:US-4689329-A
优先权日:1986-02-04
标 题:5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
发明人：CARMOSIN RICHARD J; CARSON JOHN R
权利人:MCNEILAB INC
摘要:Octahydroindolizidines and corresponding ketones of the formulae (I) and (II): (I) (II) where A is a 3-7 carbon or hetero-containing ring, R1 is a substituent, n is 0-6 and x is 0-3. Also, pharmaceutical compositions for treating pain containing (I) or (II) and methods for synthesis and use as well as novel intermediates in the synthesis.