Sodium 1,1-Cyclopropyldicarboxylate置于盐酸体系中,用 水 作为反应溶剂,化学反应生成 1,1-环丙基二羧酸 参考文献:Tong,Jian-Ying; Sun,Na-Bo; Wu,Hong-Ke,Journal Of The Chemical Society Of Pakistan,2013,Vol. 35,# 5,P. 1349-1353 标题:Tong,Jian-Ying; Sun,Na-Bo; Wu,Hong-Ke,Journal Of The Chemical Society Of Pakistan,2013,Vol. 35,# 5,P. 1349-1353
专利号:US-5428116-A 优先权日:1991-02-27 标题 :Synthesis of complex polyamines for ampholyte production 发明人:RODKEY L SCOTT; DESHONG PHILIP R 权利人:UNIV TEXAS 摘要:New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the citric acid cycle. The resulting crosslinked polyamine may further react with other compounds such as an α,β-unsaturated or α-halo unsaturated carboxylic acids to prepare new ampholyte mixtures. The resulting novel ampholytes exhibit greater heterogeneity and complexity than presently prepared ampholytes, and can be used in analytical and preparative isoelectric focusing processes. n Novel ampholyte analysis process entails analyzing chemical compounds, usually ampholytes, used in isoelectric focusing processes. The ampholyte is isoelectrically focused on an immobilized pH gradient, and then immersed in a picric acid solution to cause precipitation and visualization of amphoteric species. The isoelectrically focused and visualized ampholyte compounds may be photographed or analyzed densitometrically to compare it with other isoelectrically focused and visualized ampholytes to determine relative heterogeneity of the ampholytes over given pH ranges.
专利号:US-6177572-B1 优先权日:1997-08-20 标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use 发明人:WANG FENGJIANG 权利人:SEPRACOR INC 摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.
专利号:US-10899695-B2 优先权日:2017-02-06 标 题 :Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes 发明人:MCLAREN LEE; TO DANIEL; TOVELL DAVID; ABELE STEFAN 权利人:IDORSIA PHARMACEUTICALS LTD 摘要:The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) n nwhich are described in WO 2015/186056.
专利号:WO-2024003151-A1 优先权日:2022-06-28 标 题:Chemical synthesis platform 发明人:CRONIN LEROY 权利人:UNIV GLASGOW COURT 摘要:The invention relates to a method for generating a database for chemical syntheses and a method for performing a chemical synthesis using a database. The method for generating a database comprises generating a series of instruction sets for a series of chemical syntheses from the literature, wherein each instruction set is a machine readable and executable universal language for a chemical synthesiser; assembling the series of instructions sets within a database, and making the instruction sets available for access and autonomous execution by a chemical synthesiser. The method for performing a chemical synthesis comprises accessing an instruction set from a database, providing the instruction set to a chemical synthesiser, and autonomously executing the instruction set on the chemical synthesiser thereby to perform the chemical synthesis. The invention makes use of a standardised and step-focussed syntax to describe the chemical syntheses, and a universal synthesis automation platform.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
专利号:US-2019375702-A1 优先权日:2017-02-06 标 题 :A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
[参考文献]: A Hussain K Sharba, Et Al. Synthesis Of Thiadiazoles And 1,2,4-Triazoles Derived From Cyclopropane Dicarboxylic Acid. Molecules. 2005 Sep 30;10(9):1153-60. [参考文献]: Konstantinos Petritis, Et Al. The Simultaneous Determination Of 1-Aminocyclopropane-1-Carboxylic Acid And Cyclopropane-1,1-Dicarboxylic Acid In Lycopersicum Esculentum By High-Performance Liquid Chromatography--Electrospray Tandem Mass Spectrometry. Phytochem Anal. 2003 Nov-Dec;14(6):347-51. [参考文献]: Michael B Johansen, Et Al. Expedient Synthesis Of Pyrrolo[参考文献]: Paolo Ingallinella, Et Al. Prime Site Binding Inhibitors Of A Serine Protease: Ns3/4A Of Hepatitis C Virus. Biochemistry. 2002 Apr 30;41(17):5483-92. [参考文献]: Yan-Biao Kang, Et Al. Scandium Triflate Catalyzed Cycloaddition Of Imines With 1,1-Cyclopropanediesters: Efficient And Diastereoselective Synthesis Of Multi-Substituted Pyrrolidines. Org Biomol Chem. 2006 Jan 21;4(2):299-301.
合成参考文献
摘要:Molnár, Á.; Margaretha, P., Science of Synthesis, (2009) 48, 459. 摘要:Smith, L. H. S.; Coote, S. C.; Procter, D. J., Science of Synthesis Knowledge Updates, (2010) 3, 479. 摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 223. 参考文献:10.1021/bi025603x 摘要:Ingallinella P, Fattori D, Altamura S, Steinkühler C, Koch U, Cicero D, Bazzo R, Cortese R, Bianchi E, Pessi A. Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus. Biochemistry. 2002 Apr 30;41(17):5483–92. doi: 10.1021/bi025603x.