CAS: 619-42-1; Methyl 4-Bromobenzoate

上下游产品

methanol Ethyl 4-bromobenzoate 4-Bromobenzoic acid 4-chlorobenzoyl chloride1-(4-bromophenyl)-2-(pyridin-2-yl)ethanone Ethyl 4-bromobenzoate methyl 4-(4-phenoxyphenoxy)benzoate methyl 4-phenoxybenzoate

4-溴苯甲酸置于氯化亚砜,硫酸,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.13H,反应生成 对溴苯甲酸甲酯
参考文献:布朗斯台德酸催化的芳族羧酸氯化
标题:布朗斯台德酸催化的芳族羧酸氯化
摘要:摘要 通过与作为催化剂的布朗斯台德酸反应,已经有效地进行了芳族羧酸与 Socl 2的氯化.基于这一发现,开发了一种比传统催化方法更便宜的高效催化方法.20 种底物被氯化,在很短的反应时间内提供了极好的收率.并且socl 2 /brønsted酸体系已用于更大规模的制备反应.提出了双重活化机制来证明socl 2 /brønsted酸不可替代的体系.
DOI:10.1080/10426507.2021.1903008

专利信息

专利号:EP-1641729-B1
优先权日:2003-07-09
标题:Use of functionalized onium salts as a soluble support for organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A₁⁺, X₁^-, wherein A₁⁺ represents a cation and X₁^- represents an anion.

专利号:US-2006025421-A1
优先权日:2004-06-25
标 题:Pyridyl piperazines for the treatment of CNS disorders
发明人：BRODNEY MICHAEL A
权利人:PFIZER
摘要:This invention is directed to compounds of Formula I and to pharmaceutical compositions comprising the compound of Formula I. n n where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar 1 , Ar 2 , . . . and Z are as defined in the specification. The invention is also directed to a method of treating a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, such as migraine, headache, cluster headache, anxiety, depression, etc. This invention is also directed to intermediates useful in the synthesis of compounds of Formula I.

专利号:US-8530689-B2
优先权日:2008-05-05
标 题 :Processes for the preparation of biphenyl compounds
发明人：PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J
权利人:PERCEC VIRGIL; ROSEN BRAD MATTHEW; WILSON DANIELA A; WILSON CHRISTOPHER J; UNIV PENNSYLVANIA
摘要:The invention concerns processes for the synthesis of a compound of the formula: wherein: R 1 and R 2 are each, independently, C 1 -C 12 alkyl, CO 2 R 3 , OR 4 , R 5 (OR 6 ), or C 6 -C 18 aryl; R 3 -R 6 are each, independently, C 1 -C 12 alkyl or C 6 -C 12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R 7 -0H with BH 3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R 7 is a C 2 -C 12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.

专利号:US-8013157-B2
优先权日:2006-12-20
标题:Synthesis of unsaturated piperidines from piperidones with a silyl reagent
发明人：MANI NEELAKANDHA S; MORRILL CHRISTIE
权利人:JANSSEN PHARMACEUTICA NV
摘要:Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides.

专利号:US-12398116-B2
优先权日:2020-09-10
标题:Total synthesis of alectinib
发明人：ZHOU LIHUA
权利人:SUZHOU FUDE ZHAOFENG BIOCHEMICAL TECH CO LTD
摘要:The present invention relates to a process for preparing alectinib or a pharmaceutically acceptable salt thereof. The present invention also relates to intermediate compounds which are useful in such process and to the preparation of such intermediate compounds.

专利号:WO-2008054857-A1
优先权日:2006-11-01
标 题:Process for the preparation of intermediates useful in the treatment of hiv infection
发明人：MARTIN MICHAEL TOLAR
权利人:SMITHKLINE BEECHAM CORP; MARTIN MICHAEL TOLAR
摘要:The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.