3-羟基-6-甲基吡啶置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride 吡啶,Potassium Acetate体系中,用 二氯甲烷,乙腈 作为反应溶剂,化学反应 0.33H,反应生成 2-甲基-5-吡啶硼酸 参考文献: Amide Compounds As Ion Channel Ligands And Uses Thereof[fr] Composes D'Amides Utilises En Tant Que Ligands De Canaux Ioniques Et Utilisations Correspondantes 标题: Amide Compounds As Ion Channel Ligands And Uses Thereof[fr] Composes D'Amides Utilises En Tant Que Ligands De Canaux Ioniques Et Utilisations Correspondantes
专利号:US-12428425-B2 优先权日:2020-05-04 标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN 权利人:AMGEN INC; VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:WO-2010039922-A1 优先权日:2008-10-03 标 题:Calcilytic compounds 发明人:CASILLAS LINDA N; CHARNLEY ADAM KENNETH; DEMARTINO MICHAEL P; DONG XIAOYANG; HARRIS PHILIP ANTHONY; MARQUIS ROBERT W JR; RAMANJULU JOSHI M; TROUT ROBERT 权利人:GLAXOSMITHKLINE LLC; CASILLAS LINDA N; CHARNLEY ADAM KENNETH; DEMARTINO MICHAEL P; DONG XIAOYANG; HARRIS PHILIP ANTHONY; MARQUIS ROBERT W JR; RAMANJULU JOSHI M; TROUT ROBERT 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
专利号:CN-116715622-A 优先权日:2023-06-14 标题 :Synthesis method of 2- (2-arylbutyl) pyridine compound
专利号:US-8791131-B2 优先权日:2008-09-30 标题 :Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions 发明人:CHENG HENGMIAO; JOHNSON TED WILLIAM; HOFFMAN JACQUI ELIZABETH; GUO LISA CHEN; LIU ZHENGYU 权利人:CHENG HENGMIAO; JOHNSON TED WILLIAM; HOFFMAN JACQUI ELIZABETH; GUO LISA CHEN; LIU ZHENGYU; PFIZER 摘要:The present invention is directed to compounds of Formula (I), n nand to salts thereof, their synthesis, and their use as PI3-Kα inhibitors and/or PI3-Kα/mTOR dual inhibitors.