CAS: 761-65-9; N,N-Dibutylformamide

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CAS号124200-75-5 1,3-dihydro-5,7... | CAS号124-38-9 二氧化碳 | CAS号111-92-2 二正丁胺 | CAS号67-56-1 甲醇 | CAS号64-18-6 甲酸 | CAS号201230-82-2 carbon monoxide | CAS号110-74-7 甲酸丙酯 | CAS号67-66-3 氯仿 | CAS号3405-45-6 N-甲基二丁胺 | CAS号924-16-3 N-亚硝基二丁胺 | CAS号4164-31-2 N,N-dibutylnitramide | CAS号4707-71-5 9-甲醛菲 | CAS号66-77-3 1-萘甲醛 | CAS号3218-36-8 4-联苯甲醛 | CAS号100-10-7 对二甲氨基苯甲醛 | CAS号18368-64-4 2-氯-5-甲基吡啶 | CAS号642-31-9 9-蒽醛 | CAS号70258-18-3 2-氯-5-氯甲基吡啶

三正丁胺置于吡啶,Copper(L) Chloride体系中,用 乙腈 作为反应溶剂,100.0 °C,3.0 Mpa 条件下,反应 24.0H,以70%的收率获得产物n,N-二丁基甲酰胺
参考文献:胺中c(sp3)-C(sp3)键的实际催化裂解
标题:胺中c(sp3)-C(sp3)键的实际催化裂解
摘要:与它们普遍存在的形成相比,热力学稳定的c(sp 3)-C(sp 3)单键的选择性裂解是罕见的.本文中,我们描述了在空气存在下使用均相铜基催化剂进行此类转化的一般方法.这种新颖的方法的效用证明对c α-C β在> 70度胺具有非常好的官能团耐受性键断裂.该转化建立了叔胺作为酰胺的一般合成子,并为其在例如天然产物和生物活性分子中的可扩展功能化提供了宝贵的可能性.
DOI:10.1002/anie.201903019

专利信息

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-5919969-A
优先权日:1996-06-05
标 题 :Synthesis of yellow couplers
发明人：CRAWLEY MICHAEL W
权利人:EASTMAN KODAK CO
摘要:The invention provides a method of synthesis of a image-dye forming coupler of formula (I) wherein X is a substituent linked to the coupler by an atom of oxygen, sulfur or nitrogen R1 is an alkyl or aryl group, R2 is a hydrogen atom or an alkyl group; R3 to R7 are the same or different and selected from a hydrogen atom and substituent groups; which method comprises the reaction of a compound of formula (II) wherein R and R1 are the same or different and are as defined above for R1 and X is as defined above with a compound of formula (III) wherein R2 to R7 are as defined above, in the presence of an inert organic solvent.

专利号:US-8729277-B2
优先权日:2009-04-06
标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives
发明人：YANG HU; BARALT EDUARDO J
权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO
摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:US-8552175-B2
优先权日:2009-04-23
标题:Sulfur transfer reagents for oligonucleotide synthesis
发明人：GUZAEV ANDREI P
权利人:GUZAEV ANDREI P; A M CHEMICALS INC
摘要:The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones, 5-phenyl-3H-1,2,4-dithiazole-3-thiones, and derivatives thereof as novel, efficient sulfur-transfer reagents is disclosed. Sulfur transfer from these reagents to compounds containing a P(III) atom (e.g., triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite), was studied in solution by 31 P NMR and HPLC. The sulfur transfer from title compounds was also studied in the solid-phase synthesis of oligonucleotide phosphorothioates by phosphoramidite methods. In this application, the efficiency of the sulfur transfer reaction for 2′-deoxyoligonucleotides was better than 99.5%. The novel sulfurizing agents are synthesized, at low cost, using simple chemical methods. As opposed to many sulfur transfer reagents known in the prior art such as 1,2-benzodithiol-3-one-1,1-dioxide (Beaucage reagent) and 5-ethoxy-3H-1,2,4-dithiazole-2-one (EDIT), the sulfurizing agents disclosed herein are highly stable in solution, which increases their practical and commercial value.