CAS: 83-73-8; Diiodohydroxyquinoline

该化合物是一种有机化合物,其特点是quinoline结构,在5和7个位置上有一个羟基组和两个替代碘化合物,该化合物因其在各个领域的潜在应用而闻名,包括制药和材料科学,具有各种特性,例如:一种发泡剂,它能够形成稳定的金属离子复合物,使其在分析化学中有用,并成为潜在的治疗剂;碘原子的存在,它增强了它的再活性,并能够影响其生物活动;此外,氢氧基化合物在极溶剂中具有溶解性,并能够参与氢的结合. 5,7-Diodo-8-氢氧基诺碱也因其荧光特性而闻名,对成像和感应有利;然而,处理该化合物需要谨慎,因为含碘化合物的毒性和实验室环境需要适当的安全规程.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

8-quinolinol butandioate1-(5,7-diiodoquinolin-8-yl)-4-2-(2-methyl-5-nitro-1H-imidazolyl)ethylbutandioate phthalate1-(5,7-diiodoquinolin-8-yl)-4-2-(2-methyl-5-nitro-1H-imidazolyl)ethylphthalate hydrogenchloride chloroxine 8-hydroxyquinoline-d5,7 phthalate1-(5,7-diiodoquinolin-8-yl)-4-2-(2-methyl-5-nitro-1H-imidazolyl)ethylphthalate 4-chloro-benzenesulfonic acid 5,7-diiodo-quinolin-8-yl ester

合成工艺路线路线简述

  • 合成目标产物 5,7-Diiodo-8-Quinolinol 主要起始原料 8-Hydroxyquinoline
  • 148-24-3 = 83-73-8
    反应条件:1.1 Reagents: Iodate(1-),Dichloro-,Potassium Solvents: Water
    标题:Aromatic Iodination In Aqueous Solution. A New Lease Of Life For Aqueous Potassium Dichloroiodate
    作者:Garden,S. J.; Et Al
    参考文献:Tetrahedron Letters 日期:2001 卷标:42(11) 页码:2089-2092]

    7385-89-9 = 83-73-8
    反应条件:1.1 Reagents: Triethylamine2.1 Reagents: 1,3-Diiodo-5,5-Dimethyl-2,4-Imidazolidinedione Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 12 H,Rt2.2 Reagents: Silica
    标题:Direct Phase-Transition Catalysed Monohalogenation Of 8-Amidoquinolines At C5 Position In Water
    作者:He,Xin; Et Al
    参考文献:Chemistryselect 日期:2021 卷标:6(21) 页码:5191-5194]

    148-24-3 = 83-73-8
    反应条件:1.1 Reagents: Hydrochloric Acid,Sodium Iodide,Sodium Chlorite Solvents: Methanol,Water; 40 Min,Rt
    标题:Mild And Efficient Iodination Of Aromatic And Heterocyclic Compounds With The Naclo2/nai/HCL System
    作者:Lista,Liliana; Et Al
    参考文献:Tetrahedron 日期:2008 卷标:64(1) 页码:234-239]

    148-24-3 = 83-73-8
    反应条件:1.1 Reagents: Iodate(1-),Dichloro-,Potassium
    标题:Potassium Dichloroiodate
    作者:Lima,Edson L. S.; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2003 卷标:1 页码:1-2]

    = 83-73-8
    反应条件:1.1 Reagents: 1,3-Diiodo-5,5-Dimethyl-2,4-Imidazolidinedione Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 12 H,Rt1.2 Reagents: Silica
    标题:Direct Phase-Transition Catalysed Monohalogenation Of 8-Amidoquinolines At C5 Position In Water
    作者:He,Xin; Et Al
    参考文献:Chemistryselect 日期:2021 卷标:6(21) 页码:5191-5194
Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于盐酸,Potassium Iodate,水,Potassium Iodide体系中,化学反应生成 5,7-二碘-8-羟基喹啉
参考文献:De411050
标题:De411050

海关参考信息

专利信息


专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:WO-2012149093-A1
优先权日:2011-04-26
标 题 :2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof
发明人:LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF ARMY; LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
摘要:The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

专利号:US-2006287257-A1
优先权日:2005-06-20
标 题 :Pharmaceutical compositions to treat diseases caused by mycobacterium
发明人:STOCKEL RICHARD F
权利人:STOCKEL RICHARD F
摘要:The invention teaches the synthesis of pharmaceutical composition and methods of synthesis to treat people and animals infected with a pathogenic mycobacterium. In particular the compositions of this invention are suitable for the treatment of tuberculosis, malaria, and other infections diseases caused by mycobacterium.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人:IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:WO-2012149097-A2
优先权日:2011-04-26
标 题 :Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof

专利号:US-2007148246-A1
优先权日:2005-08-11
标题:Nucleic Acid-Based Matrixes
发明人:LUO DAN; LI YOUGEN
权利人:LUO DAN; LI YOUGEN
摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.
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主要参考文献


1: Fisher AK, Walter FG, Szabo S. Iodoquinol associated seizures and radiopacity. J Toxicol Clin Toxicol. 1993;31(1):113-20. doi: 10.1128/AAC.05125-11. Epub 2011 Oct 24.
5: Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F. Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole. Antimicrob Agents Chemother. 1994 May;38(5):1157-60.
6: Mackey-Lawrence NM, Petri WA Jr. Amoebic dysentery. BMJ Clin Evid. 2011 Jan 13;2011. pii: 0918. Review.

合成参考文献


摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 249.
摘要:British Journal of Pharmacology and Chemotherapy., 3(44), 1948
摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#03304
摘要:The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 423
摘要:BASNUEVO JG, KREDI E, CORTEGUERA H, VIRELLES F. [Antiparasitic therapeutics: 2 new cases of hepatic ameobic abscess treated with chloroquine-diiodohydroxyquinoline]. Rev Kuba Med Trop Parasitol. 1958 Jan;14(1-6):4–9.
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