CAS: 1078-21-3; 4-Amino-3-Phenylbutyric Acid Hydrochloride

上下游产品

2-oxo-4-phenyl-3-ethoxycarbonylpyrrolidine 4-phenylpyrrolidin-2-one 3-cyano-3-phenyl propionic acid hydrogenchloride 4-phenylpyrrolidin-2-one (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide 4-((tert-butoxycarbonyl)amino)-3-phenylbutanoic acid

3-氰基-3-苯丙酸置于palladium On Activated Charcoal 氢气体系中,用 溶剂黄146 用作溶剂,化学反应生成4-氨基-3-苯基丁酸盐酸盐
参考文献:Cignarella; Fontanella; Aresi,Farmaco,Edizione Scientifica,1968,Vol. 23,# 4,P. 321-343
标题:Cignarella; Fontanella; Aresi,Farmaco,Edizione Scientifica,1968,Vol. 23,# 4,P. 321-343

专利信息

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:EP-3599246-A1
优先权日:2018-07-25
标题 :Means and methods for synthesizing precursors of y-aminobutyric acid (gaba) analogs
发明人：POELARENDS GERRIT JAN; BIEWENGA LIEUWE; VAN DER MEER JAN-YTZEN; PODDAR HARSHWARDHAN; THANGAVELU SARAVANAN
权利人:UNIV GRONINGEN
摘要:The invention relates to the fields of drug development and biocatalysis, more specifically to a biocatalytic route for asymmetric synthesis of precursors of y-aminobutyric acid (GABA) analogs. Provided is an isolated mutant 4-oxalocrototonate tautomerase (4-OT) enzyme comprising the following mutations (i) leucine at position 8 substituted with a tyrosine (L8Y) or a phenylalanine (L8F); (ii) methionine at position 45 substituted with a tyrosine (M45Y); and (iii) phenylalanine at position 50 substituted with an alanine (F50A), wherein the positions are numbered according to the amino acid sequence of 4-OT ofPseudomonas putida.Also provided is a method for the synthesis of a precursor for the pharmaceutically relevant enantiomer of a GABA analog, comprising (i) providing a y-nitroaldehyde using the 4-OT mutant enzyme, followed by (ii) subjecting the thus obtained y-nitroaldehyde to an enzymatic oxidation reaction catalyzed by an aldehyde dehydrogenase (EC 1.2.1.3).

专利号:US-2013310555-A1
优先权日:2012-05-21
标题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions

专利号:CN-120041848-A
优先权日:2025-02-18
标 题 :Method for electrochemically synthesizing chiral beta-ester nitrile and application of chiral beta-ester nitrile in synthesis of baclofen and rolipram

专利号:US-2017008863-A1
优先权日:2008-02-22
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions