CAS: 1193-02-8; 4-Aminobenzenethiol

该化合物是一种芳香化合物,其特征是苯环上的一种矿(-NH2)和一种硫醇(-SH)功能组. 这种双重功能使得它成为有机合成的多功能中间体,特别是在生产药品,染料和农用化学物方面. 它的硫醇组允许对金属表面有很强的约束力,使其在地表改造和纳米技术应用中有用. 该化合物在标准条件下具有良好的稳定性,可以在氨基或硫醇组中进行选择性反应,从而能够精确的衍生. 它的高度纯度和一贯性使得它成为需要控制功能化的研究和工业应用的可靠选择.

结构式图片

相似化合物

1849-36-1 22948-02-3 104-96-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

bis(4-aminophenyl)disulfide 4-thi°Cyanatoaniline di(p-nitrophenyl) disulfide bis-(4-amino-phenyl)-trisulfide N,N-bis-(2-hydroxy-ethyl)-4-(2-hydroxy-ethylsulfanyl)-anilineN,N-bis-(2-hydroxy-ethyl)-4-(2-hydroxy-ethylsulfanyl)-aniline [3-(4-acetylamino-phenylsulfanyl)-propyl]-trimethyl-ammonium; iodide [2-(4-acetylamino-phenylsulfanyl)-ethyl]-diethyl-methyl-ammonium; iodide 4-acetamidothiophenol

合成工艺路线路线简述

    4-硝基苯硫醇置于硼烷铵络合物,Nickel(II) Chloride Hexahydrate,1,2-双(二苯基膦)乙烷体系中,用 乙醇 用作溶剂,以78 %的收率获得4-氨基苯硫酚
    参考文献:均相镍催化氨-硼烷功能化硝基芳烃化学选择性转移氢化
    标题:均相镍催化氨-硼烷功能化硝基芳烃化学选择性转移氢化
    摘要:以nh 3 Bh 3为氢源,成功建立了均相ni催化硝基芳烃高选择性转移加氢反应.选择性还原多种官能团,以非常好到高产率提供相应的苯胺.此外,可以制备否则难以获得的药物活性化合物.
    Doi:10.1039/d3Cc05173K

    专利信息


    专利号:US-10150160-B2
    优先权日:2014-12-04
    标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
    发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
    权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
    摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

    专利号:US-9845289-B2
    优先权日:2014-08-01
    标题 :Process for the synthesis of Dapsone and its intermediates
    发明人:BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA; GABOARDI MAURO; PALLANZA GIUSEPPE
    权利人:SEEGPHARM SA
    摘要:A process for the synthesis of Dapsone and intermediates thereof are described.

    专利号:US-7531694-B2
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
    发明人:VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
    权利人:LUNDBECK PHARMACEUTICALS ITALY
    摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

    专利号:US-2009099218-A1
    优先权日:2007-09-17
    标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
    发明人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
    权利人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
    摘要:This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.

    专利号:US-9546317-B2
    优先权日:2006-11-27
    标 题:Synthesis of water soluble non-toxic nanocrystalline quantum dots and uses thereof
    发明人:SHIH WEI-HENG; SHIH WAN Y; LI HUI
    权利人:SHIH WEI-HENG; SHIH WAN Y; LI HUI; UNIV DREXEL
    摘要:An economic, direct synthetic method for producing water soluble ZnS QDs that are ready for bioconjugation is provided. The method can produce aqueous ZnS QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. The aqueous ZnS QDs are stable in biological fluids over a long period of time. In addition, non-toxic ZnS QDs have been produced with good photoluminescence properties.

    专利号:US-7674881-B2
    优先权日:2005-10-07
    标题:Convergent synthesis of proteins by kinetically controlled ligation
    发明人:KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
    权利人:UNIV CHICAGO
    摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Abel T Demissie, Et Al. Growth Of Thin, Anisotropic, π-Conjugated Molecular Films By Stepwise "Click" Assembly Of Molecular Building Blocks: Characterizing Reaction Yield, Surface Coverage, And Film Thickness Versus Addition Step Number. J Am Chem Soc. 2015 Jul 15;137(27):8819-28.
    [参考文献]: Chongwen Wang, Et Al. Polyethylenimine-Interlayered Core-Shell-Satellite 3D Magnetic Microspheres As Versatile Sers Substrates. Nanoscale. 2015 Nov 28;7(44):18694-707.
    [参考文献]: Homan Kang, Et Al. Direct Identification Of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System For High-Throughput Bioanalysis. Sci Rep. 2015 May 28:5:10144.
    [参考文献]: Hye-Eun Lee, Et Al. Concave Rhombic Dodecahedral Au Nanocatalyst With Multiple High-Index Facets For Co2 Reduction. Acs Nano. 2015 Aug 25;9(8):8384-93.
    [参考文献]: M A Casado-Rodriguez, Et Al. Synthesis Of Vinyl-Terminated Au Nanoprisms And Nanooctahedra Mediated By 3-Butenoic Acid: Direct Au@pnipam Fabrication With Improved Sers Capabilities. Nanoscale. 2016 Feb 28;8(8):4557-64.

    合成参考文献


    参考文献:10.1107/s1600536811014577
    摘要:Neuba A, Flörke U, Henkel G. 2-[2-(Benzyl-sulfan-yl)phen-yl]-1,1,3,3-tetra-methyl-guanidine. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1202–3.
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