CAS: 127852-28-2; (R)-1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethanol

相似化合物

368-63-8 225920-05-8 30071-93-3

上下游产品

3,5-bis(trifluoromethyl)phenylmagnesium bromide acetaldehyde 3,5-bis(trifluoromethyl)phenyl methyl ketone (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 3,5-bis(trifluoromethyl)styrene 3,5-bis(trifluoromethyl)phenyl methyl ketone (S)-3,5-bis(trifluoromethyl)-1-phenylethanol (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

(Alphar)-Alpha-甲基-3,5-二(三氟甲基)-苯甲醇乙酸酯置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 3.0H,以98%的收率获得(R)-1-[3,5-二(三氟甲基)苯基]乙醇
参考文献:改良的kagan酰胺:合成和用作手性溶剂,用于NMR中基于氢键的手性鉴别†
标题:改良的kagan酰胺:合成和用作手性溶剂,用于NMR中基于氢键的手性鉴别†
摘要:设计,合成并筛选了一种改性的卡根酰胺,N-((S)-1-(3,5-双(三氟甲基)苯基)乙基)-3,5-二硝基苯甲酰胺[(S)-2 ]用于区分光学活性基材的溶剂化剂(csa).提议的通过csa识别分析物的手性异构体的作用方式是基于氢键的.手性酰胺,亚砜,α-取代的酸,α-羟基酮,环氧酮和带有(S)-2的n-保护的氨基酸的两个异构体的1 H NMR信号已被很好地解析,可用于测定光学纯度的实际应用.还对csa进行了筛选,以检测19 F NMR.
Doi:10.1039/c5Ra06959A

专利信息

专利号:US-2008090274-A1
优先权日:2004-12-16
标 题 :Process For The Synthesis Of (S)-1-(3,5-Bis (Trifluoromethyl)-Phenyl-Ethan-1-Ol
发明人：MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
权利人:MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
摘要:The present invention is concerned with novel processes for the preparation of (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol (CAS # 30071-93-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6403793-B2
优先权日:2000-06-12
标 题 :Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：PYE PHILIP J; ROSSEN KAI
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3.5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmethyl) mopholine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6395898-B1
优先权日:2000-06-09
标 题:Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：MCNAMARA JAMES M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:WO-03043575-A3
优先权日:2001-11-19
标题 :Process for the synthesis of (r)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol and esters thereof by dynamic kinetic resolution
发明人：BROXTERMAN QUIRINUS BERNARDUS; VERZIJL GERARDUS KAREL MARIA
权利人:MERCK & CO INC; BROXTERMAN QUIRINUS BERNARDUS; VERZIJL GERARDUS KAREL MARIA
摘要:The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol and esters thereof via dynamic kinetic resolution. These compounds are useful as intermediates in the synthesis of compounds which possess pharmacological activity.

专利号:US-6469164-B2
优先权日:2000-06-08
标题:Process for the synthesis of (2R, 2-alpha-R)-4-benzyl-2-[1-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-1,4-oxazine-3-one
发明人：BRANDS KAREL M JOS; PAYACK JOSEPH F; PYE PHILIP J
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-1,4-oxazin-3-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.