CAS: 140-53-4; 4-Chlorobenzyl Cyanide

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CAS号4251-65-4 对氯苯乙醛 | CAS号14856-74-7 对氯苄氧基三甲基硅烷 | CAS号10442-39-4 氰化四丁基胺 | CAS号873-76-7 4-氯苄醇 | CAS号99839-78-8 Benzenepropanam... | CAS号2942-58-7 氰代磷酸二乙酯 | CAS号104-83-6 4-氯氯苄 | CAS号6965-39-5 2-(4-氯苯基)-N-羟基乙脒 | CAS号106-39-8 对氯溴苯 | CAS号3277-80-3 4-CHLOROPHENYL ... | CAS号55474-40-3 1-氰基-1-(对氯苯基)-2-丁酮 | CAS号51630-58-1 氰戊菊酯 | CAS号57676-51-4 4-氯苯乙酰肼 | CAS号50921-39-6 1-(4-氯苯基)-1-环丁羧酸 | CAS号3152-15-6 3-(4-氯苯基)-2,5-呋喃二酮 | CAS号14439-61-3 4'-氯地西泮 | CAS号5033-28-3 4-氯-N-羟基苯羧酰亚胺 | CAS号51631-50-6 3-甲基-2-(4-氯苯基)丁酰氯 | CAS号4251-65-4 对氯苯乙醛

对氯苯乙酸置于草酰氯,三乙胺,三氟乙酸酐体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 48.0H,反应生成对氯苯乙腈
参考文献:未保护的苄基四唑的锂取代.
标题:未保护的苄基四唑的锂取代.
摘要:1H-四唑在现代药物化学中起着重要的作用,但是很少有对其进行修饰的方法.许多现存的方案要求使用难以除去的n-烷基保护基,排除了将产物用作羧酸酯生物等排体,这是四唑类在药物中的主要作用.我们在此报告了苄基四唑的方便,无保护基团的锂取代反应方案.在0oc下用n-Buli进行金属化,然后进行亲电捕集,可得到一系列α-官能化的苄基四唑,收率高达91%.
Doi:10.1021/acs.Orglett.9B02633

专利信息

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:WO-2022170218-A1
优先权日:2021-02-05
标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
发明人：QIN TIAN; YANG YANGYANG; TSIEN JET
权利人:UNIV TEXAS
摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-3940393-A
优先权日:1974-06-21
标题 :Synthesis of 2,6-diaminopyrimidines
发明人：GREENSPAN GEORGE; REES RICHARD W; RUSSELL PETER B
权利人:AMERICAN HOME PROD
摘要:New, substituted, 2,6-diaminopyrimidines are disclosed. These compounds are useful as anti-malarial agents. The oxygenation of pyrimethamine by fungi is also disclosed.

专利号:US-2007135437-A1
优先权日:2005-03-04
标题:Modulation of neurodegenerative diseases
发明人：BENJAMIN DANIEL E; HENRIE ROBERT N II; ERRICO MONICA A; REX BRIAN T; BRACKEN JUSTIN D; SCOTT SEAN
权利人:ALSGEN INC
摘要:Methods and compositions are disclosed for selectively decreasing protein levels in a central nervous system, meningial, immune system, blood, or muscle cell by administrating a pharmacological agent. In particular, methods and compositions that interfere with SOD-1 protein synthesis or stability, and decrease cellular levels of the protein are disclosed.

专利号:WO-2021078995-A1
优先权日:2019-10-25
标 题 :Selective polypeptide synthesis stalling assay and compound
发明人：STROUS GERARDUS JACOBUS ANTONIUS MARIA; MOL JAN ADRIANUS; VAN DER VELDEN LIEKE MARIE; KLUMPERMAN JUDITH; MAAS PETRUS EMMANUEL MARIE; PIET DENNIS PATRICK; DE KLERK-SPRENKELS NANDA ELISABETH; TIJHUIS JOHANN HEINRICH; VIÉTOR HENDRIK ENGELBERTUS; MAURICE MADELON MARIA; VAN DER KRIFT FELIX
权利人:UMC UTRECHT HOLDING BV; UNIV UTRECHT HOLDING BV; BIMINI BIOTECH B V
摘要:The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.