CAS: 1529-41-5; (3-Chlorophenyl)Acetonitrile

相似化合物

1878-65-5 41904-40-9 58357-84-9

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3-氯苯乙醇置于盐酸羟胺,Tert-Butylammonium Hexafluorophosphate(V),Calcium(II) Trifluoromethanesulfonate体系中,用 N,N-二甲基乙酰胺 用作溶剂,以92%的收率获得间氯氰苄
参考文献:路易斯酸催化醛合成腈
标题:路易斯酸催化醛合成腈
摘要:在 Dma 溶剂中,在路易斯酸催化剂体系 (Ca(Otf) 2 /bu 4 Npf 6 ) 和盐酸羟胺中,在 120 oc下研究了醛类向其相应腈类的一锅转化.所开发的合成方法在常规加热条件下进行,并获得了优异的产品收率.
Doi:10.1016/j.Tetlet.2022.153711

专利信息

专利号:WO-8103020-A1
优先权日:1980-04-22
标 题 :Triazine synthesis
发明人：HARRIS R
权利人:COMMW SCIENT IND RES ORG; HARRIS R
摘要:A process for the synthesis of substituted 1,3,5-triazine compounds of the general formula: (FORMULA) wherein Rs and Rs, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamino, arylamino, alkyl-arylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that Rs and Rs are not both halogen); and Rs is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryl; comprises reaction of a substituted halomethyleneiminium salt with a substituted N-cyanoamidine, N-cyanoguanidine, N-cyanocarbamimidate or N-cyanocarbamidothioate. Substituted 1,3,5-triazine compounds having fungal germination inhibition properties are also disclosed. The following compounds 1) 2-chloro-4-phenyl-1,3,5-triazine, 2) 2-chloro-4-phenoxymethyl-6-phenyl-1,3,5-triazine, 3) 2-N-methylphenylamino-4-phenyl-1,3,5-triazin, 4) 2-chloro-4-cyanomethyl-6-phenyl-1,3,5-triazine are also disclosed and claimed.

专利号:WO-2014202765-A1
优先权日:2013-06-21
标题 :Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
发明人：STAVBER GAJ; GAZIC SMILOVIC IVANA; CLUZEAU JEROME; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:CN-105358534-A
优先权日:2013-04-23
标 题:New synthesis method, new intermediate and production method of 8-chloro-1-methyl-benzo[d]azepine

专利号:WO-2014173928-A1
优先权日:2013-04-23
标题 :Novel synthetic process to 8-chloro-1-methyl-benzo[d]azepine, novel intermediates and the production thereof
发明人：GAJ STAVBER; CLUZEAU JEROME; RICHTER FRANK; LAUS GERHARD; GAZIC SMILOVIC IVANA
权利人:LEK PHARMACEUTICALS
摘要:The present invention is directed to a simple and economical process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -benzo[ d ]azepine via novel intermediates and a highly selective asymmetric synthesis leading to enantiopure ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -benzo[ d ] azepine or its ( S )-enantiomer, in order to avoid or overcome chemical optical resolution.