CAS: 1737-36-6; 4-Chloro-3-(Trifluoromethyl)Benzoic Acid

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CAS号1735-54-2 4-氯-3-(三氟甲基)苯甲腈 | CAS号1735-55-3 4-氯-3-三氟甲基苯甲酰氯 | CAS号115591-64-5 Methyl 4-chloro...

3-三氟甲基-4-氯苯腈置于sodium Hydroxide,乙醇,水,盐酸体系中,用 乙醇 用作溶剂,化学反应 15.0H,反应生成3-三氟甲基-4-氯苯甲酸
参考文献:Amine Compounds
标题:Amine Compounds
摘要:提供了一种化合物,具有抑制免疫反应并减少不良药物反应的活性,该化合物在化疗中用于预防或治疗各种自身免疫性疾病,包括系统性红斑狼疮,慢性类风湿关节炎,I型糖尿病,炎症性肠病,胆汁性肝硬化,葡萄膜炎,多发性硬化或其他疾病,慢性炎症性疾病,癌症,淋巴瘤或白血病,器官或组织移植的抗性或对移植的排斥.提供了具有s1P1/edg1受体激动剂作用的新型胺类化合物,可能是这些化合物的立体异构体或消旋体,或这些化合物,立体异构体或消旋体的药理学上可接受的盐,水合物或溶剂合物,或这些化合物,立体异构体,消旋体,盐,水合物或溶剂的前药.

专利信息

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:US-9763953-B2
优先权日:2005-09-22
标题:Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
发明人：MAELICKE ALFRED
权利人:GALANTOS PHARMA GMBH; NEURODYN LIFE SCIENCES INC
摘要:The present invention refers to compounds that, in addition to enhancing the sensitivity to acetylcholine and choline, and their exogenous agonists, of neuronal cholinergic receptors and/or acting as cholinesterase inhibitors and/or neuroprotective agents, have enhanced blood-brain barrier permeability in comparison to their parent compounds. The compounds are derived (either formally by their chemical structure or directly by chemical synthesis) from natural compounds belonging to the class of amaryllidaceae alkaloids e.g., galantamine, narwedine and lycoramine, or from metabolites of said compounds. The compounds of the present invention can either interact as such with their target molecules, or they can act as “pro-drugsâ€?, in the sense that after reaching their target regions in the body they are converted by hydrolysis or enzymatic attack to the original parent compound and react as such with their target molecules, or both. The compounds of this invention may be used as medicaments.

专利号:CA-2693182-A1
优先权日:2007-06-29
标 题:Pyrimidine compounds, methods of synthesis thereof, and use thereof in the treatment of raf kinase-mediated disorders

专利号:CA-2693182-C
优先权日:2007-06-29
标题:Pyrimidine compounds, methods of synthesis thereof, and use thereof in the treatment of raf kinase-mediated disorders