CAS: 28319-77-9; (R)-2,3-Dihydroxypropyl (2-(Trimethylammonio)Ethyl) Phosphate

相似化合物

36314-47-3 33049-08-0 20559-16-4

上下游产品

all cis-5,8,11,14,17-eicosapentaenoic acid L-dipalmitoylphosphatidylcholine (R)-1,2-diacetoxy glycerylphosphoryl choline siladenoserinol Adioleoylphosphatidylcholine 1,2-dipentadecanoyl-sn-glycero-3-phosphorylcholine 1,2-dioleoyl-sn-glycero-3-phosph°Choline 1,2-didecanoyl-sn-glycero-3-phosph°Choline

(R)-4-Bromomethyl-2-Methyl-2-Ethyl-1,3-Dioxolane置于sodium Hydroxide,硫酸体系中,用 异丙醇,乙醇,水 用作溶剂,化学反应 30.0H,以67.9%的收率获得甘磷酸胆碱
参考文献:一种l-α-甘磷酸胆碱的化学合成方法
标题:一种l-α-甘磷酸胆碱的化学合成方法
摘要:本发明公开了一种使用氯化胆碱盐,R‑卤代甘油和酮类试剂为原料制备l‑α‑甘磷酸胆碱的方法,所得l‑α‑甘磷酸胆碱粗品经吸附柱,混床柱等纯化处理最终得到高纯度l‑α‑甘磷酸胆碱.由本发明化学合成方法制备而得的甘磷酸胆碱纯度高,反应条件步骤简单,收率稳定,同时不会造成环境污染,具备工业化生产条件.

专利信息

专利号:US-2022280429-A1
优先权日:2021-03-03
标 题:Tunable leukocyte-based biomimetic nanoparticles and methods of use
发明人：ZINGER ASSAF YOSEF; TARABALLI FRANCESCA
权利人:METHODIST HOSPITAL
摘要:Disclosed are liposomal formulations and biomimetic proteolipid nanoparticles that possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types. Leukocyte-based biomimetic nanoparticles are disclosed that incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the in vivo behavior of these nanoparticles and alter their efficacy. Here it is shown that, while increasing the protein:lipid ratio to a maximum of 1:20 (wt./wt.) maintained the nanoparticle's structural properties, increasing protein content resulted in improved targeting of inflamed endothelium in two different animal models. The combined use of a microfluidic, bottom-up approach, and the tuning of key synthesis parameters enabled the synthesis of reproducible, biomimetic nanoparticles for the improved targeted nanodelivery of a variety of inflammatory-based conditions, including particular cancers such as human breast cancer, and TNBC, in particular.

专利号:US-10736912-B2
优先权日:2005-05-23
标 题 :Compositions containing PUFA and/or uridine and methods of use thereof
发明人：WURTMAN RICHARD; RICHARDSON INGRID
权利人:MASSACHUSETTS INSTITUE OF TECH; MASSACHUSETTS INST TECHNOLOGY
摘要:This invention provides methods of enhancing brain development; increasing or enhancing intelligence; increasing or enhancing synthesis and levels of phospholipids, synapses, synaptic proteins, and synaptic membranes by a neural cell or brain cell, comprising contacting a subject or a pregnant or nursing mother thereof with a composition comprising an omega-3 fatty acid, an omega-6 fatty acid, and/or uridine, a metabolic precursor thereof, or a combination thereof.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:WO-2024035945-A1
优先权日:2022-08-12
标 题:Efficient synthesis of very-long-chain polyunsaturated fatty acids
发明人：Wade Alexander; GORUSUPUDI ARUNA; BERNSTEIN PAUL; RAINIER JON; RALLABANDI RAMESHU
权利人:UNIV UTAH RES FOUND
摘要:The rare non-dietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) uniquely found in retina and a few other tissues play a clinically significant role in retinal degeneration and development, but their physiological and interventional research has been hampered by scarcity of pure VLC-PUFAs. Disclosed herein are methods of making fatty acids, including VLC-PUFAs, and methods of using these fatty acids in, for example, treating eye disorders and supplementing the diet of a female subject who is pregnant, desiring to become pregnant, or lactating. Also disclosed are compositions containing fatty acids and methods of making and using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-2010233782-A1
优先权日:2005-09-27
标 题:Isolated phospholipid-protein particles
发明人：KATZEN FEDERICO; FLETCHER JULIA; KUDLICKI WIESLAW; BEECHEM JOSEPH; WANG LILIN
权利人:LIFE TECHNOLOGIES CORP
摘要:Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include a scaffold protein such as apolipoprotein or an amphipathic alpha helix containing (“AAHCâ€?) protein, in which higher yields of soluble protein are produced than in the absence of the scaffold protein. The scaffold proteins may be provided in an in vitro protein synthesis system associated with lipid or not associated with lipid. The scaffold protein may be provided as a protein per se or may be encoded by a nucleic acid template and co-expressed with the protein of interest. The invention also provides compositions and kits for synthesis of proteins in soluble form, in which the compositions and kits include cell extracts for protein expression and isolation.