CAS: 31127-80-7; 5-Acetamido-N,N'-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodoisophthalamide

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CAS号76801-93-9 5-氨基-2,4,6-三碘-N... | CAS号108-24-7 乙酸酐 | CAS号64-19-7 冰醋酸 | CAS号31122-75-5 5-Acetamido-2,4... | CAS号616-30-8 3-氨基-1,2-丙二醇 | CAS号66108-95-0 碘海醇 | CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号37441-29-5 5-氨基-2,4,6-三碘异酞酰氯 | CAS号92339-11-2 碘克沙醇 | CAS号66108-95-0 碘海醇 | CAS号70894-76-7 5-[acetyl(2-hyd...

N,N'-Bis(2,3-Diacetoxypropyl)-5-Acetamido-2,4,6-Triiodoisophthalamide置于水,Sodium Hydroxide体系中,化学反应生成 5-(乙酰氨基)-N,N'-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺
参考文献:碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用
标题:碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用
摘要:本发明涉及一种碘海醇杂质的合成方法,特别涉及一种碘海醇杂质f的合成方法及其在碘海醇杂质g,杂质h和杂质m合成中的应用,属于医药技术领域.该方法是以5‑硝基‑1,3‑苯二甲酸二甲酯(式2化合物)和2,3‑二羟基丙胺为原料制备式3化合物,式3化合物与氢气还原反应制得式4化合物,式4化合物再与一氯化碘反应得到碘海醇杂质f.本发明以5‑硝基‑1,3‑苯二甲酸二甲酯(式2化合物)为起始原料,合成5‑氨基‑n,N'‑双(2,3‑二羟基丙基)‑二碘‑1,3‑苯二甲酰胺(式1化合物)再以化合物式1为起始原料合成杂质g,杂质h和杂质m,为碘海醇质量控制提供合格的杂质对照品.

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-7696381-B1
优先权日:2009-07-21
标题 :Alternative dimerisation reagents for synthesis of iodixanol
发明人：BERG ARNE; DUGSTAD HARALD; GACEK MICHEL; GULBRANDSEN TRYGVE; STRANDE PER
权利人:GE HEALTHCARE AS
摘要:This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?) to iodixanol.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.

专利号:US-8962887-B2
优先权日:2009-07-21
标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
发明人：HOMESTAD OLE MAGNE
权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.

专利号:US-2011021822-A1
优先权日:2009-07-21
标题:continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
发明人：ASKILDSEN ARNE; CERVENKA JAN; HUSSAIN KHALID; SORENSEN THORE JARLE; MALTHE-SORENSSEN DIDRIK
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by crystallisations, filtration, and washing of Compound A.