CAS: 3886-69-9; (R)-(+)-1-Phenylethylamine

上下游产品

CAS号67-56-1 甲醇 | CAS号2743-01-3 N-(4-methoxyphe... | CAS号36283-44-0 (R)-N-(1-苯乙基)乙酰胺 | CAS号98-86-2 苯乙酮 | CAS号247236-71-1 (RS)-2-methyl-N... | CAS号368447-71-6 (2S)-2-phenyl-2... | CAS号2627-86-3 (S)-(-)-α-甲基苄胺 | CAS号113-24-6 丙酮酸钠 | CAS号10549-15-2 α-氧代-N-[(R)-1-苯... | CAS号46022-05-3 (1R,2R)-1,2-环己烷二甲酸 | CAS号473-08-5 α-香附酮 | CAS号36283-44-0 (R)-N-(1-苯乙基)乙酰胺 | CAS号5933-40-4 R-N-甲基-苯乙胺 | CAS号40648-92-8 (S,S)-(-)-双(Α-甲... | CAS号98-85-1 苏合香醇 | CAS号32366-25-9 1-Phenylethyl azide | CAS号4747-11-9 (1-Phenoxyethyl... | CAS号142999-60-8 (3S)-N-[(1R)-1-...

苯乙酮肟置于[rh(1,2-Bis(2,5-Dimethylphospholan-1-yl)Ethane)(Cod)](Bf4) 氢气,铁粉,Potassium Carbonate,三氟乙酸体系中,用 甲醇,乙醇,水,乙酸乙酯 作为反应溶剂,20.0~65.0 °C,620.53 Kpa 条件下,反应 48.0H,反应生成 R(+)-Alpha-甲基苄胺
参考文献:有效合成手性苯乙胺:烯,三氟乙酰胺的制备,不对称氢化和轻度脱保护
标题:有效合成手性苯乙胺:烯,三氟乙酰胺的制备,不对称氢化和轻度脱保护
摘要:从酮类到对映体富集的芳基烷基胺的温和有效途径已得到开发.首次成功地从肟中合成烯和三氟酰胺并进行不对称加氢,得到了高度对映体富集的三氟乙酰胺(94-98%ee).在温和的条件下(k 2 Co 3,Meoh / H2O)释放出相应的苯乙基酰胺.另外,发现了josiphos配体在烯乙酰胺和烯三氟乙酰胺的不对称氢化中的新应用.
DOI:10.1016/j.Tetlet.2006.06.135

专利信息

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-8476441-B2
优先权日:2009-01-29
标 题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
发明人：CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN
权利人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN; TRINITY COLLEGE DUBLIN
摘要:(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2023278959-A1
优先权日:2020-05-04
标题:Synthesis of Optically Active Indoline Derivatives Via Ruthenium(II)-Catalyzed Enantioselective C-H Functionalization
发明人：CUI XIN; LI ZHONG-YUAN; CHAMINDA LAKMAL HETTI HANDI
权利人:UNIV MISSISSIPPI STATE
摘要:Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C—H bond and activating the unfunctionalized C—H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

专利号:US-4000169-A
优先权日:1975-01-27
标题 :Asymmetric synthesis of optically active compounds
发明人：CHAN KA-KONG; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:Asymmetric synthesis of optically active 3,7,11-trimethyl-dodecan-1-ol, an intermediate for producing optically active vitamin E, from isovaleraldehyde or prenal including intermediates in this synthesis.