五氟丙酰氟置于caesium Fluorid Monohydrate体系中,化学反应生成 五氟丙酸 参考文献:Development Of Technology Of Perfluoroethyl Isopropyl Ketone Production 标题:Development Of Technology Of Perfluoroethyl Isopropyl Ketone Production 摘要:Synthesis Of Perfluoroethyl Isopropyl Ketone By An Interaction Of Hexafluoropropene With Perfluoropropionic Acid Fluoride Or Hexafluoropropene Oxide Was Examined. Interchangeability Of Perfluoropropionic Acid Fluoride And Hexafluoropropene Oxide Was Demonstrated. The Features Of Perfluoroethyl Isopropyl Ketone Synthesis Were Studied In Polar Aprotic Solvents On Catalysts: Alkali Metal Fluoride. A Method For Obtaining Perfluoroethyl Isopropyl Ketone By Direct Catalytic Reaction In A Tubular Reactor Without Use Of Solvents Was Suggested And Investigated. The Mechanism Of Interaction Was Considered. The Main Impurities Resulting In Obtaining Perfluoroethyl Isopropyl Ketone Were Determined. The Methods Of Cleaning Perfluoroethyl Isopropyl Ketone Were Worked Out. DOI:10.1134/s1070427213030154
专利号:EP-0946571-B1 优先权日:1996-12-12 标 题:Synthesis of bis trialkylsilylamide and resulting composition 发明人:FORAT GERARD 权利人:RHODIA CHIMIE SA 摘要:The invention concerns the synthesis of bis trialkylsilylamide which consists in: subjecting the amide to the action of a trialkylsilyl halide on an amide bearing a Rf group in the presence of a base whose halide, or halohydrate is insoluble in the medium and in the presence of a covalent and non-hydrophilic solvent. The invention is applicable to organic synthesis.
专利号:US-5859288-A 优先权日:1995-03-24 标 题:Reagent and process for the synthesis of oxysulphide-containing fluorine-containing organic derivatives 发明人:FORAT GERARD; MAS JEAN-MANUEL; SAINT-JALMES LAURENT 权利人:RHONE POULENC CHIMIE 摘要:The invention relates to a reagent which is useful for the synthesis of oxysulphide-containing fluorine-containing organic derivatives by reacting with an oxide of sulphur, especially sulphur dioxide, characterized in that it comprises: a) a fluorocarboxylic acid of formula Ew-CF2-COOH where Ew is an electron-withdrawing group or atom which is at least partially salified by an organic or inorganic cation, and b) an aprotic polar solvent; and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid. This reagent can be used by heating in order to form fluorine-containing sulphinic or sulphonic acids.
专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-2012301720-A1 优先权日:2009-11-16 标题 :Metal island coatings and method for synthesis 发明人:KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY 权利人:KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY; BASF SE 摘要:The present invention relates to methods for synthesis of metallic island coatings with tunable island coverage and morphology on a variety of substrates. Particularly, the present invention relates to substrates coated with one or more metal islands and the use of said island-coated substrates.
专利号:US-2005106689-A1 优先权日:2002-03-21 标 题:Synthesis of aminocrotonates 发明人:BRAUN MAX; BRAUKMUELLER SASKIA 权利人:SOLVAY FLUOR & DERIVATE 摘要:3-aminocrotonate compounds, e.g. diesters, which are substituted on the C-4 atom by at least two chlorine and/or fluorine atoms, are produced by reacting corresponding acetoacetate compounds with ammonia and primary and secondary amines while simultaneously or subsequently eliminating water. The reaction is carried out in the presence of onium salts formed from primary or secondary amines and carboxylic acids. Preferably, two phases are formed; one phase containing the crotonate compound product with a good degree of purity and the other phase containing the onium salt and water.
专利号:US-7338932-B2 优先权日:2000-05-11 标题 :Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments 发明人:CLAUSEN HENRIK; BENNETT ERIC PAUL; HASSAN HELLE; REIS CELSO ALBUQUERQUE 权利人:GLYCOZYM APS 摘要:Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to lectins. This invention discloses that the putative lectin domains of GalNAc-transferase isoforms, GalNAc-T4, -T7, -T2, and -T3, are functional and recognize carbohydrates, glycopeptides, and peptides and discloses the lectin domains of GalNAc-T1-T16. These lectin domains have different binding specificities and modulate the functions of GalNAc-transferase isoforms differently. Novel methods for identification of inhibitors or modulators of binding activities mediated by lectin domains of polypeptide GalNAc-transferases are disclosed. Direct binding activity of GalNAc-transferase lectins has been demonstrated for the first time and methods to measure lectin mediated binding of isolated lectins or enzymes with lectin domains are disclosed. The present invention specifically discloses a novel selective inhibitor of polypeptide GalNAc-transferase lectin domains, which provides a major advancement in that this inhibitor and related inhibitors sharing common characteristics of activity bind lectin domains without serving as acceptor substrate for glycosyltransferases involved in synthesis of O-glycans. This inhibitor is represented by the β-anomeric configuration of GalNAc-benzyl, GalNAcβ-benzyl. Methods for inhibiting intracellular transport, cell surface expression, and secretion of mucins and O-glycosylated glycoproteins without affecting O-glycosylation processing are disclosed using the novel selective inhibitor identified.
[参考文献]: Chunyu Yu, Et Al. Quantification Of Free Polyamines And Their Metabolites In Biofluids And Liver Tissue By Uhplc-Ms/ms: Application To Identify The Potential Biomarkers Of Hepatocellular Carcinoma. Anal Bioanal Chem. 2015 Sep;407(22):6891-7. [参考文献]: Hong Yan, Et Al. Occurrence Of Perfluorinated Alkyl Substances In Sediment From Estuarine And Coastal Areas Of The East China Sea. Environ Sci Pollut Res Int. 2015 Feb;22(3):1662-9. [参考文献]: Meng-Jia Chen, Et Al. Decomposition Of Perfluorooctanoic Acid By Ultraviolet Light Irradiation With Pb-Modified Titanium Dioxide. J Hazard Mater. 2016 Feb 13:303:111-8. [参考文献]: Murielle Gaugain, Et Al. 6-Iso-Chlortetracycline Or Keto Form Of Chlortetracycline Need For Clarification For Relevant Monitoring Of Chlortetracycline Residues In Food. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(7):1105-15. [参考文献]: Péter Jankovics, Et Al. Exploring The Possibilities Of Capacitively Coupled Contactless Conductivity Detection In Combination With Liquid Chromatography For The Analysis Of Polar Compounds Using Aminoglycosides As Test Case. J Pharm Biomed Anal. 2015 Aug 10:112:155-68.
合成参考文献
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 261. 摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 2(299), 1950 摘要:Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 10(3)(13), 1966 摘要:S95 | PFASANEXCH | PFAS List from the NORMAN PFAS Analytical Exchange Activity | DOI:10.5281/zenodo.6384309 摘要:S125 | FLUOROIONS | Fluorinated Ionic Liquids Suspect List | DOI:10.5281/zenodo.15348301.