CAS: 480-19-3; 3,5,7-Trihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-4H-Chromen-4-One

该化合物是一种自然形成的富稀胶片胶片,具有强效抗氧化性特性.它的独特结构使得能够有效地清除自由基,防止氧化性压力和细胞损伤. 已经发现Isohamnetin表现出抗炎活动,成为各种需要抗氧化剂和抗炎效果的药物应用的潜在候选产品.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号78386-02-4 3'-O-methyl-4',... | CAS号103839-19-6 5,7-dihydroxy-2... | CAS号6743-92-6 异鼠李素-3-O-半乳糖苷 | CAS号604-80-8 水仙苷 | CAS号6758-51-6 异鼠李素-3,7-O-二葡萄糖苷 | CAS号107603-09-8 isorhamnetin 3-... | CAS号153-18-4 芦丁 | CAS号65982-77-6 BENZOYLOXYPHLOR... | CAS号1334307-40-2 3-(3-methoxy-4-... | CAS号108-73-6 间苯三酚 | CAS号99-50-3 原儿茶酸 | CAS号117-39-5 槲皮素 | CAS号121-34-6 香草酸

合成工艺路线路线简述

  • 合成目标产物 Isorhamnetin 主要起始原料 2-Propen-1-One, 3-(4-Hydroxy-3-Methoxyphenyl)-1-(2,4,6-Trihydroxyphenyl)-, (2E)-
  • (文献来源)合成步骤主要原料 2-Propen-1-One, 3-(4-Hydroxy-3-Methoxyphenyl)-1-(2,4,6-Trihydroxyphenyl)-, (2E)-
3,5,7,4'-Tetrahydroxy-8,3'-Dimethoxyflavone-3-O-β-D-Glucopyranoside置于氢气体系中,用 水 作为反应溶剂,化学反应生成 异鼠李素
参考文献:来自景天英亩的黄酮醇苷
标题:来自景天英亩的黄酮醇苷
摘要:摘要 从景天的地上部分分离到了三种新的黄酮醇苷,即异鼠李素3-(2T´-乙酰)葡萄糖苷,Limocitrin 7-Glucoside 和limocitrin 3,7-Diglucoside.已知化合物槲皮素,异鼠李素及其 3-和 3,7-二糖苷,异鼠李素 7-葡萄糖苷和利莫替林及其 3-葡萄糖苷也被鉴定出来.化合物的结构是通过光谱和化学方法确定的.
DOI:10.1016/0031-9422(88)83050-4

海关参考信息

专利信息


专利号:WO-2025080233-A1
优先权日:2023-10-09
标 题:A method for the synthesis of the isorhamnetin metabolite
发明人:KIRICI DAMLA; DEMIRCI BETUL; DEMIRCI FATIH
权利人:SELCUK UNIV; ANADOLU UNIV
摘要:The present invention relates to a method for the synthesis of isorhamnetin metabolite from the quercetin molecule and the isorhamnetin metabolite synthesized by this method. In this method, isorhamnetin is synthesised from quercetin molecule by microbial transformation of Aspergillus flavus. The method of the present invention provides the synthesis of isorhamnetin with 18.20% yield in a short time and at low cost.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人:GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2014357576-A1
优先权日:2013-05-31
标题:Methods for enhancement of muscle protein synthesis
发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

专利号:WO-2015040533-A1
优先权日:2013-09-19
标题:Methods for enhancing muscle protein synthesis during energy deficit
发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
权利人:PREMIER NUTRITION CORP
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.
北京海步国际医药科技发展有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.hopelife.cn
电话: 86-10-67886402👤
📞北京海步国际医药科技发展有限公司 ⚠️参考联系方式

销售电话:86-10-67886402
邮箱:apis@hopelife.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
西安三江生物工程有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.sanjiangbio.com.cn
电话: 029-86515551👤
📞西安三江生物工程有限公司 ⚠️参考联系方式

销售电话:029-86515551
邮箱:Sanjiang@sanjiangbio.com.cn
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
成都科程生物科技开发有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证,请用户仔细辨别,谨慎交易。
数据来源于公开网络搜索,平台未作核实,请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.cogon-chem.com
电话: 028-85171192👤
📞成都科程生物科技开发有限公司 ⚠️参考联系方式

销售电话:028-85171192
邮箱:cogon_chem@hotmail.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领,请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实,百琢研不参与任何交易。企业认领注册入口→

⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明:本展台内容基于各搜索引擎等公开数据整理,仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议, 请通过页面底部联系方式告知我们,我们会尽快处理。
第 1 / 1 页
现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Abdal Dayem A, Choi HY, Kim YB, Cho SG. Antiviral effect of methylated flavonol isorhamnetin against influenza. PLoS One. 2015 Mar 25;10(3):e0121610. doi: 10.1371/journal.pone.0121610. eCollection 2015.
2: Zhang BY, Wang YM, Gong H, Zhao H, Lv XY, Yuan GH, Han SR. Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). Int J Clin Exp Pathol. 2015 Jan 1;8(1):25-37. eCollection 2015.
3: Wang X, Zhong W. Isorhamnetin attenuates collagen-induced arthritis via modulating cytokines and oxidative stress in mice. Int J Clin Exp Med. 2015 Sep 15;8(9):16536-42. eCollection 2015.

合成参考文献


参考文献:10.2147/ceg.s17114
摘要:Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol. 2011;4():75–119.
参考文献:10.1007/s00425-011-1474-0
摘要:Hall D, Kim KH, De Luca V. Molecular cloning and biochemical characterization of three Concord grape (Vitis labrusca) flavonol 7-O-glucosyltransferases. Planta. 2011 Dec;234(6):1201–14. doi: 10.1007/s00425-011-1474-0.
参考文献:10.1074/jbc.m111.251967
摘要:Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, Beer S, Pfeffer K, Coers J, Taylor GA. Immunity-related GTPase M (IRGM) Proteins Influence the Localization of Guanylate-binding Protein 2 (GBP2) by Modulating Macroautophagy. Journal of Biological Chemistry. 2011 Sep;286(35):30471–80. doi: 10.1074/jbc.m111.251967.
参考文献:10.1017/s0007114511003242
摘要:Egert S, Wolffram S, Schulze B, Langguth P, Hubbermann EM, Schwarz K, Adolphi B, Bosy-Westphal A, Rimbach G, Müller MJ. Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. Br J Nutr. 2012 Feb;107(4):539–46. doi: 10.1017/s0007114511003242.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知