CAS: 6902-77-8; (1R,4As,7As)-Methyl 1-Hydroxy-7-(Hydroxymethyl)-1,4A,5,7A-Tetrahydrocyclopenta[c]Pyran-4-Carboxylate

相似化合物

24512-63-8 69977-52-2 206755-40-0

上下游产品

geniposide geniposide choline chloride genipin 1-O-β-D-isomaltoside cerbinal 1-methoxygenipin

京尼平甙置于immobilized β-Glucosidase体系中,用 乙酸乙酯 作为反应溶剂,以63.08%的收率获得产物京尼平
参考文献:固定化β-葡萄糖苷酶在两相水-有机系统中将栀子苷转化为京尼平
标题:固定化β-葡萄糖苷酶在两相水-有机系统中将栀子苷转化为京尼平
摘要:京尼平是京尼平苷的生物活性化合物,是一种天然交联剂.为改进京尼平的制备工艺,研究了在水-有机两相体系中固定化β-葡萄糖苷酶水解京尼平苷制备京尼平.β-葡萄糖苷酶以海藻酸钠为载体,采用交联包埋法固定化.最佳反应温度,Ph值和时间分别为55°C,4.5和2.5小时.为了减少京尼平水解和副产物产生,反应在包含乙酸乙酯和乙酸钠缓冲液的水-有机两相系统中进行.通过HPLC,Uv,Ir和NMR分析产物.京尼平的收率为47.81%,纯度超过98%(HPLC).
DOI:10.3390/molecules16054295

专利信息

专利号:WO-2023044581-A1
优先权日:2021-09-24
标题 :Flow synthesis of porous collagen microparticles for versatile tissue engineering applications
发明人：SINGH SUSHANT; SAMIEI EHSAN; GUENTHER AXEL; VERES TEODOR
权利人:GOVERNING COUNCIL UNIV TORONTO; NAT RES COUNCIL CANADA; SINGH SUSHANT
摘要:A microfluidic flow synthesis method for collagen-based microparticles. Macro-porous fibrillar microparticles of pure collagen and composite collagen-GAG were formed, where the particle size and porosity were controlled by the flow synthesis parameters such as precursor flow rates. Using human dermal fibroblasts (hDFB) and umbilical cord derives mesenchymal stem cells (ucMSC), the capacity of the presented collagen and collagen-GAG microparticles to serve as cell culture substrates has been shown, to enable casting of tissues, forming spheroids, and as shear-thinning bioinks for bioprinting. At high packing densities, jammed collagen-based microparticles along with cells constitute a shear-thinning bioink for extrusion bioprinting applications. Bioprinted constructs exhibit a high porosity matrix due to the space between the microparticles, facilitating macromolecular transport, and cell proliferation and migration.

专利号:US-8771719-B2
优先权日:2002-08-12
标题 :Synthesis of a bone-polymer composite material
发明人：SHIMP LAWRENCE A; WINTERBOTTOM JOHN M; BOYCE TODD M; KNAACK DAVID
权利人:SHIMP LAWRENCE A; WINTERBOTTOM JOHN M; BOYCE TODD M; KNAACK DAVID; WARSAW ORTHOPEDIC INC
摘要:A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

专利号:US-8658711-B2
优先权日:2010-09-29
标题 :Process for the synthesis of methacrylate-derivatized type-1 collagen and derivatives thereof
发明人：SHREIBER DAVID; GAUDET IAN
权利人:SHREIBER DAVID; GAUDET IAN; UNIV RUTGERS
摘要:Methods for synthesizing a methacrylate-derivatized type-I collagen in which methacrylic acid is reacted with a carboxylic acid activating reagent in the presence of a carbodiimide to form a methacrylic acid with an activated carboxylic acid group, which is then reacted with free amino groups on type-I collagen to form a collagen methacrylamide. Methacrylate-derivatized collagen, cross-linked collagens formed therefrom and products containing the cross-linked collagen are also disclosed.

专利号:US-9567430-B2
优先权日:2011-12-02
标 题 :Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
发明人：SALTZMAN W MARK; JIANG ZHAOZHONG; ZHOU JIANGBING; LIU JIE
权利人:UNIV YALE
摘要:Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

专利号:WO-2013082529-A1
优先权日:2011-12-02
标题 :Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
发明人：SALTZMAN W MARK; JIANG ZHAOZHONG; ZHOU JIANGBING
权利人:UNIV YALE
摘要:Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticies therefrom, and methods of using the nanoparticies for drug delivery are disclosed. The nanoparticies can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticies are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticies are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

专利号:US-2018193528-A1
优先权日:2014-07-24
标 题 :Printable morphogenetic phase-specific chitosan-calcium-polyphosphate scaffold for bone repair
发明人：MÃœLLER WERNER ERNST LUDWIG GEORG; SCHRÖDER HEINRICH-CHRISTOPH WILHELM FRIEDRICH; WANG XIAOHONG
权利人:MUELLER WERNER ERNST LUDWIG GEORG
摘要:This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone N tissue engineering, as a bio mimetic 3-phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression/activation of bone alkaline phosphatase (Phase 3: hydroxyapatite-biomineral.