CAS: 754-05-2; Trimethyl(Vinyl)Silane

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CAS号83268-94-4 2-allyl-2-metho... | CAS号83268-89-7 2-cyclopropyl-2... | CAS号83268-92-2 2-methoxy-1,1,1... | CAS号75-94-5 乙烯基三氯硅烷 | CAS号993-07-7 三甲基硅烷 | CAS号75-77-4 三甲基氯硅烷 | CAS号75-01-4 乙烯基氯 | CAS号74-86-2 乙炔 | CAS号58207-97-9 Tributyl[(1E)-2... | CAS号54388-71-5 (trimethylsilyl... | CAS号16054-34-5 (Z)-1,4-bis(tri... | CAS号16054-35-6 2,7-Disila°Ct-4... | CAS号53304-31-7 trimethyl(3-tri... | CAS号110434-24-7 1-cyclohex-2-en... | CAS号1115-16-8 Pentanoic acid,... | CAS号10575-36-7 hexa-1,4-dien-3-one | CAS号1104636-73-8 乙烯基硼酸甲基亚氨基二乙酸酯 | CAS号4312-99-6 1-辛烯-3-酮 | CAS号18178-59-1 Silane, 1,2-eth... | CAS号3555-47-3 四(三甲基硅氧基)硅烷

乙烯基三氯硅烷置于ch3Mgbr体系中,用 二丁醚 作为反应溶剂,以91.4%的收率获得产物乙烯基三甲基硅烷
参考文献:Studies In Silico-Organic Compounds. Xxi. Alkyl And Phenyl Derivatives Of Vinyltrichlorosilane
标题:Studies In Silico-Organic Compounds. Xxi. Alkyl And Phenyl Derivatives Of Vinyltrichlorosilane
摘要:
DOI:10.1021/jo50010A016

专利信息

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-8722886-B1
优先权日:2012-11-13
标题:Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
发明人：CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY
权利人:CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY; BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.

专利号:US-6096913-A
优先权日:1999-06-10
标 题:Production of metal-ligand complexes
发明人：NORMAN JOHN ANTHONY THOMAS; SENZAKI YOSHIHIDE; ROBERTS DAVID ALLEN
权利人:AIR PROD & CHEM
摘要:In a process for the synthesis of a first metal-ligand complex, M +n (L - ) n , where n≧1, from a metal compound precursor and a ligand precursor, where the metal of the metal compound precursor may during the synthesis change to a valence in excess of n; the improvement, to suppress formation of a second metal-ligand complex of the metal with a valence in excess of n, of adding the elemental form of the metal to the synthesis of the first metal-ligand complex.

专利号:US-11713329-B2
优先权日:2018-12-10
标 题 :Intermediates useful in the preparation of halichondrin compounds and methods for preparing the same
发明人：XU WEIPING
权利人:BEIJING TIENYI LUFU PHARMATECH CO LTD
摘要:The invention relates to intermediates useful in the preparation of halichondrin compounds, methods for preparing the same and use thereof, such as halichondrins, eribulin, or their analogs. The intermediates, the methods and use thereof are used for the synthesis of the C20-C26 fragment of halichondrin compounds. The raw materials in the synthetic route of the invention are cheap and easily obtained, the sources and the qualities of the raw materials are reliable. The choice of the methods useful in the synthesis of chiral central structures are based on the structural characteristics of the reactants, thus effectively improving the synthesis efficiency, reducing the difficulties and risks of product quality control, and avoiding the use of highly toxic and expensive organotin catalysts to significantly decrease costs and improve environmental friendliness.

专利号:US-6015918-A
优先权日:1998-11-10
标 题 :Allyl-derived precursor and synthesis method
发明人：ZHUANG WEI-WEI; NGUYEN TUE; STECKER GREG MICHAEL; EVANS DAVID RUSSELL; HSU SHENG TENG
权利人:SHARP LAB OF AMERICA INC
摘要:A Cu(hfac) allyl-derived ligand precursor has been provided. The ligand includes group consisting of alkyl, phenyl, trialkylsilane, trialkoxylsilane, halodialkylsilane, dihaloalkylsilane, trihalosilane, triphenylsilane, alkoxyl, halogen, chloroformate, cynanide, cycloalkyl, cycloalkylamine, alkyl ether, isocyanate, and pentafluorobenzene. Examples of the allyl-derived ligand precursors have proved to be stable at room temperatures, and sufficiently volatile at higher temperatures. Copper deposited with this precursor has low resistivity and high adhesive characteristics. A synthesis method has been provided which produces a high yield of the above-described precursors, including a Cu(hfac)(allyltrimethylsilane) precursor.

专利号:US-7820831-B2
优先权日:2002-09-11
标 题:Compounds comprising a thiocarbonyl-sulfanyl group which can be used for the radical synthesis of α-perfluoroalkylamine compounds
发明人：ZARD SAMIR; GAGOSZ FABIEN; TOURNIER LUCIE
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for preparing compounds having the formula (VIII).