CAS: 99-55-8; 2-Methyl-5-Nitroaniline

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CAS号7745-93-9 2-溴-4-硝基甲苯 | CAS号95-53-4 邻甲苯胺 | CAS号67-56-1 甲醇 | CAS号201230-82-2 carbon monoxide | CAS号121-14-2 2,4-二硝基甲苯标准溶液 | CAS号136833-45-9 Benzoic acid, 4... | CAS号36192-16-2 N,N-dimethyl-N'... | CAS号120-66-1 乙酰邻甲苯胺 | CAS号95-80-7 2,4-二氨基甲苯 | CAS号108-88-3 甲苯 | CAS号35588-36-4 2-氯-N-(2-甲基-5-硝... | CAS号5428-54-6 5-硝基-2-甲基苯酚 | CAS号7597-18-4 6-硝基吲唑 | CAS号5434-30-0 5'-氨基-2'-甲基乙酰苯胺 | CAS号404844-11-7 N-[4-甲基-3-(4-吡啶... | CAS号19871-37-5 4-methyl-N-(2-m... | CAS号2879-79-0 N-(2-甲基-5-硝基苯基)乙酰胺 | CAS号2835-95-2 5-氨基邻甲酚 | CAS号95-80-7 2,4-二氨基甲苯 | CAS号99-60-5 2-氯-4-硝基苯甲酸

2,4-二硝基甲苯置于氢气体系中,用 四氢呋喃,水 作为反应溶剂,110.0 °C,5.0 Mpa 条件下,反应 1.5H,反应生成 2-氨基-4-硝基甲苯
参考文献:基于fe-n-c @ Cnts的高活性非贵金属催化剂,用于硝基芳烃的还原†
标题:基于fe-n-c @ Cnts的高活性非贵金属催化剂,用于硝基芳烃的还原†
摘要:过渡金属-氮-碳(mc)材料的研究表明,它们在一些重要的传统反应中具有催化作用.但是,Mc-C的活性仍需要进一步提高,而mc-C催化剂的真正活性中心仍在争论中.在这项工作中,通过对fecl 3,菲咯啉和cnt的热解制备了一种用于硝基芳烃加氢的有效fe-n-c @ Cnt.碳纳米管上负载的fe-n-c比活性碳上负载的fe-N-c活性高得多,显示出碳纳米管的促进作用.表征结果表明,Fe-N系c的高活性主要归因于形成ε-铁3N,它是氢化反应的活性位点.接触到活性中心的氮/碳原子可以作为桥梁,通过溢出效应传输解离的氢原子.首次在连续流动条件下在固定床反应器上测试了fe-n-c的催化性能,并可以在300多个小时内平稳地催化反应.
DOI:10.1039/c6Ra20666B

专利信息

专利号:US-8334381-B2
优先权日:2006-11-16
标题 :Process for the preparation of intermediates useful in the synthesis of imatinib
发明人：FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO
权利人:FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO; ITALIANA SINT SPA
摘要:It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.

专利号:US-2010015076-A1
优先权日:2005-12-23
标题 :Polymer structure reacting with keratin, synthesis and use thereof
发明人：ZANOTTI RUSSO MATTEO; BARBINI NICOLA
权利人:EUDERMIC S R L
摘要:Novel (co)polymeric structures having functional groups making possible, under conditions that are safe for human use, the formation of chemical bonds with human keratin, and in particular with the keratin present in hair, eyelashes and eyebrows, skin, nails, lips, the oral mucosa and tissues of the external genital organs are disclosed; the invention also relates to the synthesis of such (co)polymeric structures and the use thereof in the fields of cosmetics and medicine.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6541653-B2
优先权日:2001-04-26
标题 :Synthesis of carbamate through low pressure heterogeneous oxidative carbonylation of amines
发明人：CHUANG STEVEN S C; CHI YAWU; CHEN BEI; TOOCHINDA PISANU
摘要:The process disclosed herein satisfies the need in the art for an industrially viable oxidative carbonylation catalytic system, and is capable of producing carbamates at a significantly higher rate than those processes reported in journal and patent literature. This reaction process takes place via a reaction mechanism that does not involve drastic conditions. Specifically, the catalytic system of the present invention employs Group VIII metal catalysts and/or copper-based catalysts with halide promoters to produce carbamates through heterogeneous oxidative carbonylation at atmospheric pressure and relatively non-drastic temperatures in a gas-solid carbonylation process.