CAS: 103-88-8; 4-Bromoacetanilide

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621-38-5 2564-02-5 24568-11-4

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CAS号64-19-7 冰醋酸 | CAS号106-40-1 对溴苯胺 | CAS号75-36-5 乙酰氯 | CAS号108-24-7 乙酸酐 | CAS号60-35-5 乙酰胺 | CAS号589-87-7 对溴碘苯 | CAS号103-84-4 N-乙酰苯胺 | CAS号99-90-1 4-溴苯乙酮 | CAS号20980-00-1 Ethanethioamide... | CAS号54446-36-5 4-溴苯基苯胺 | CAS号35704-19-9 4'-氰基乙酰基苯胺 | CAS号586-78-7 对溴硝基苯 | CAS号326-66-9 4-溴-2-氟乙酰苯胺 | CAS号5304-21-2 6-溴-2-甲基-1,3-苯并噻唑 | CAS号38985-79-4 2-乙酰胺基-5-溴苯甲酸 | CAS号89-52-1 N-乙酰邻氨基苯酸 | CAS号40465-45-0 4-氰基苯异氰酸酯 | CAS号7726-95-6 溴素 | CAS号20980-00-1 Ethanethioamide...

N-乙酰苯胺置于溴,Calcium Bromide体系中,用 乙腈 用作溶剂,化学反应 0.17H,以99%的收率获得4'-溴乙酰苯胺
参考文献:瞬间而轻松 溴化 在工业上很重要 芳香族化合物置于水 使用可回收的 溴化钙2-溴2 系统
标题:瞬间而轻松 溴化 在工业上很重要 芳香族化合物置于水 使用可回收的 溴化钙2-溴2 系统
摘要:各种工业上重要的溴化中间体已使用aq. 溴化钙2-溴2 室温下在水性条件下可作为有效且可回收的溴化试剂的系统,无需金属 催化剂或酸性添加剂.结构多样苯酚 和 苯胺 吸电子性强的衍生物 团体 例如羧酸 硝基的 和 甲酰对溴化试剂表现出显着的反应性,并在非常短的反应时间内就以92-98%的收率进行了溴化,纯度高(> 99%).无溶剂的条件是绿色化学的特征,不仅被用于反应,而且在反应结束时被用于产物的分离.的回收溴化氢 通过其中和,从而产生额外的工业上重要的数量 溴化钙2已经设计和开发.溴化试剂已经过回收和再生,使用具有几乎相同的选择性和分离的收率的再生溴化试剂,在新批处理之后的整个过程中,该过程可重复进行多达4个循环,从绿色方法的角度来看,这似乎是最有前途的方法有机合成.
Doi:10.1039/c1Gc15359E

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-8304550-B2
优先权日:2007-11-30
标题 :Process for the catalytic synthesis of diaryl ethers
发明人：COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER
权利人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER; SALTIGO GMBH
摘要:Described is a process for preparing diaryl ethers of the formula (I)n nAr—O—Ar′  (I)n n In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, n by reacting an aryl of formula (II) or a aryloxy salt of formula (III)n nAr—OH  (II)n nAr—OR  (III)n n In which Ar has the same meaning as in formula (I) and R is an alkali metal, n with an aryl or heteroaryl bromide of formula (IV)n nAr′—Br  (IV)n n In which Ar′ has the same meaning as in formula (I), n characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).