CAS: 128-44-9; 1,2-Benzothiazol-3(2H)-One 1,1-Dioxide Sodium Salt

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81-07-2 50978-45-5 15448-99-4

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专利信息

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-2010137421-A1
优先权日:2006-11-08
标题 :Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
发明人：THEODORAKIS EMMANUEL; BATOVA AYSE
权利人:THEODORAKIS EMMANUEL; BATOVA AYSE
摘要:Provided herein are compounds that are inducers of apoptosis activators of caspases and pharmaceutically acceptable derivatives thereof. Also provided are methods of synthesis of the compounds and methods for treatment of diseases in which there is uncontrolled cell growth and spread of abnormal cells, such as cancers, by administering the compounds.

专利号:US-4898952-A
优先权日:1987-05-29
标 题 :Regioselective synthesis of a 1,5-disubstituted pyrazole
发明人：MURRAY WILLIAM V; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a beta -dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): (I) (IV)

专利号:US-8212071-B2
优先权日:2005-09-19
标题:Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
发明人：KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; RAO V GOVARDHAN; TIWARI ANAND PRAKASH
权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; RAO V GOVARDHAN; TIWARI ANAND PRAKASH; TEVA PHARMA
摘要:The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.

专利号:US-6025502-A
优先权日:1999-03-19
标题:Enantopselective synthesis of methyl phenidate
发明人：WINKLER JEFFREY DAVID; AXTEN JEFFREY M; KRIM LORI
权利人:UNIV PENNSYLVANIA
摘要:The invention relates to an enantioselective method of making methylphenidate and derivatives thereof. The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer thereof. Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives thereof.

专利号:WO-2017137818-A1
优先权日:2016-02-12
标 题 :Synthesis and application of an antimicrobial active
发明人：K RAKESH RATNAM; SARVIYA SAMIR
权利人:SALICYLATES & CHEMICALS
摘要:The disclosure Synthesis & Application of a Novel Antimicrobial active provides a method of synthesis of organic complex starting from fatty acid with a free base bioactive molecule containing nitrogen atoms. The reaction is usually conducted in refluxing alcohol. The product is synthesized by a acid-base reaction whereby the acid molecule is capable of donating a proton, to the free base molecule resulting in the formation of the desired complex. These complexes are very effective antimicrobial active against a variety of bacteria, fungi, protozoa, helminths and viruses. The process is suitable for large-scale synthesis and involves simple and high-yielding techno feasible chemical transformations using low-cost commercially available raw materials. The complex has wide spread use in human personal care, industries and household applications, as the disclosed chemical has antimicrobial activity against gram positive, gram negative bacteria, yeast, mold, fungi.