CAS: 198474-90-7; Boc-Phe(3,4-Dif)-Oh

相似化合物

205445-51-8 198560-43-9 31105-90-5

上下游产品

CAS号85118-01-0 3,4-二氟溴苄 | CAS号266360-51-4 2-acetamido-3-(... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号31105-90-5 L-3,4-二氟苯丙氨酸

2-Acetylamino-2-(3,4-Difluorobenzyl)Malonic Acid Diethyl Ester置于sodium Hydroxide,Aspergillus Genus Acylase,Sodium Acetate体系中,用 甲醇,对二甲苯,水 用作溶剂,化学反应 53.0H,反应生成Boc-L-3,4-二氟苯丙氨酸
参考文献:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
标题:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
摘要:A Complete Set Of Difluorophenylalanines In The L-Configuration [l-(F-2)Phe] (Namely,L-(2,3-F-2)Phe,L-(2,4F(2))Phe,L-(2,5-F-2)Phe,L-(2,6-F-2)Phe,L-(3,4-F-2)Phe,L-(3,5-F-2)Phe) Was Prepared And Incorporated Into The Thrombin Receptor-Tethered Ligand Peptide Sfllrnp To Identify The Phenyl Hydrogens Of The Phe-2 Residue Involved In The Ch/pi Receptor Interaction. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(99)02191-7

专利信息

专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.