CAS: 198479-63-9; 5-(Benzyloxy)-2-(4-(Benzyloxy)Phenyl)-3-Methyl-1H-Indole

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CAS号35081-45-9 1-[4-(苄氧基)苯基]-2... | CAS号51388-20-6 4-苄氧基苯胺盐酸盐 | CAS号4495-66-3 4'-苄氧基苯丙酮 | CAS号52068-30-1 4-苄氧基苯肼盐酸盐 | CAS号100-39-0 溴化苄 | CAS号70-70-2 4-羟基苯丙酮; 对羟基苯丙酮 | CAS号198479-82-2 ethyl 2-[4-[[3-... | CAS号198481-32-2 1-[[4-[2-(氮杂环庚烷... | CAS号198480-21-6 1-[4-(2-(氮杂环庚烷-...

4-苄氧基-1-硝基苯置于tin(Ll) Chloride体系中,用 乙二醇乙醚,乙醇 用作溶剂,化学反应 30.0H,反应生成3-甲基-5-苄氧基-2-(4-苄氧基苯基)-1H-吲哚
参考文献:哌嗪酮类化合物及其应用
标题:哌嗪酮类化合物及其应用
摘要:本发明属于医药技术领域,涉及1‑乙基‑4‑{4‑[5‑羟基‑2‑(4‑羟基苯基)‑3‑甲基‑1H‑吲哚‑1‑基]丁基}哌嗪‑2,3‑二酮及其医药应用.1‑乙基‑4‑{4‑[5‑羟基‑2‑(4‑羟基苯基)‑3‑甲基‑1H‑吲哚‑1‑基]丁基}哌嗪‑2,3‑二酮以及其立体异构体和药学上适用的盐,其结构式如下:1‑乙基‑4‑{4‑[5‑羟基‑2‑(4‑羟基苯基)‑3‑甲基‑1H‑吲哚‑1‑基]丁基}哌嗪‑2,3‑二酮以及该类化合物药学上适用的酸加成的盐可以与现有药物合并或单独使用作为雌激素受体调节剂,用于治疗或预防与雌激素功能相关的各种疾病,如:骨丢失,骨折,骨质疏松,潮热,Ldl胆固醇水平升高,心血管疾病,认知功能缺损,大脑退化疾病,焦虑,由于雌激素缺乏所致的抑郁,性功能障碍,高血压,视网膜变性和癌症,尤其是骨质疏松症.

专利信息

专利号:US-7968732-B1
优先权日:2010-09-07
标 题 :Process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole
发明人：DIVI MURALI KRISHNA PRASAD; RAO BOLINENI NAGESWARA; SURESH DANDU VENKATA
权利人:DIVIS LAB LTD
摘要:The present invention is related to a process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-Indole (formula-1, a useful intermediate for the synthesis of bazedoxifene) using 4-benzyloxy propiophenone and 4-benzyloxy phenyl hydrazine hydrochloride.

专利号:US-10844047-B2
优先权日:2018-06-21
标题:Process for the preparation of bazedoxifene
发明人：FERRARI MASSIMO; ZANI DANIELE DE; VEZZOSI STEFANO; BELOTTI PAOLO
权利人:ERREGIERRE SPA
摘要:The invention relates to a process for preparation of the compound 3-methyl-5-benzyloxy-2-(4-benzyloxyphenyl)-1H-indole 5, an intermediate for the synthesis of bazedoxifene and bazedoxifene acetate.

专利号:EP-1025077-B1
优先权日:1997-10-15
标题 :Novel aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN RICHARD; REN JIANXIN
权利人:WYETH CORP
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having formula (I) wherein: R?1 and R2¿ are, independently, selected from H; C¿1?-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R?3, R4, R5, and R6¿ are independently selected from H, halogen, -NO¿2?, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R?1¿, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO¿2?-R?1, -SO¿2-Ar, -CO-R1, -CO-Ar, -CO¿2-R?1, or -CO¿2?-Ar; and Y is selected from a) the moiety (i) wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:US-6268504-B1
优先权日:1997-10-15
标题 :Aryloxy-alkyl-dialkylamines
发明人：RAVEENDRANATH PANOLIL; ZELDIS JOSEPH; VID GALINA; POTOSKI JOHN R; REN JIANXIN; IERA SILVIO
权利人:AMERICAN HOME PROD
摘要:The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, -NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SO2-Ar, -CO-R1, -CO-Ar, -CO2-R1, or -CO2-Ar; and Y is selected from a) the moiety:wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of -O-, -NH-, -N(C1C4 alkyl)-, -N=, and -S(O)n-.

专利号:CN-112110845-B
优先权日:2019-06-21
标题:Synthesis method of bazedoxifene and analogues thereof