CAS: 28940-11-6; 7-Methyl-3,4-Dihydro-2H-1,5-Benzodioxepin-3-One

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CAS号534-07-6 1,3-二氯丙酮 | CAS号452-86-8 4-甲基邻苯二酚 | CAS号816-39-7 1,3-二溴丙酮 | CAS号52589-39-6 4-甲基儿茶酚二乙酸二甲酯

3,4-二羟基甲苯置于potassium Tert-Butylate,Potassium Carbonate体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 2.57H,反应生成西瓜酮
参考文献:通过具有定性嗅觉评估的新型合成路线合成苯并二氧戊环酮类似物
标题:通过具有定性嗅觉评估的新型合成路线合成苯并二氧戊环酮类似物
摘要:海洋气味剂代表香料工业中的次要但不同类的物质,其7-甲基-2 ħ-1,5-苯并二氧-3-(4 ħ)-酮(1)的商业上称为使calone 1951 ®,合成海洋香气化学领域的第一名.为了确定哪个的特性海洋气味的程度使calone 1951 ®对应于在该分子的苯并部分取代,各种芳族取代基分别并入benzodioxepinone结构(方案1,表3).鉴于在将专利文献推导类似物12-18时遇到的困难尤其是具有吸电子取代基的那些,实施了一种替代的合成方案,用于以有利的收率构建所有类似物(方案4,表3).通过表氯醇的环氧裂解(方案3)形成羟基保护的二卤代烷基化剂24,使醚化反应有利于二卤代取代和随后的分子内环封闭(26A-G).Thp脱保护,然后将醇27A-G氧化为酮12-18提供了苯并二氧杂戊酮产品的一般途径.取代基性质对气味活性的影响揭示了嗅觉特性的不同范围(表4).
Doi:10.1002/hlca.200790085

专利信息

专利号:WO-2024052739-A1
优先权日:2022-09-08
标 题 :Method for the synthesis of benzodioxepinone compounds and intermediates thereof
发明人：NANDAN DR SANTOSH RAGHU; KORI AMITKUMAR RAMBIHARI; SHARMA BASANTKUMAR RAJKUMAR; SATISH SOHAL; CHITRAL ROHAN KAILASH; S JAYASHREE PUTTUR
权利人:AMBERNATH ORGANICS PVT LTD
摘要:A method for the preparation of benzodioxepinone compounds of formula (I), and the intermediates thereof, wherein, R 1 is independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 alkyl, C 2 - C 6 alkenyl and C 3 -C 6 cycloalkyl; n represents integer 0-3.

专利号:DE-19911103-A1
优先权日:1999-03-12
标 题 :Generation of stabilized, ultra-short light pulses and their application for the synthesis of optical frequencies

专利号:US-3647479-A
优先权日:1969-10-28
标 题 :Method of flavoring food by addition of benzoxepin-3-ones and benzodioxepin-3-ones
发明人：BEEREBOOM JOHN J; CAMERON DONALD P; STEPHENS CHARLES R
权利人:PLIZER INC
摘要:Benzoxepin-3-ones and Benzodioxepin-3-ones, prepared by a novel synthesis, are useful as flavor and odorant agents for foods and perfumes respectively to impart a watermelonlike taste and odor.

专利号:CN-116237066-A
优先权日:2022-12-30
标题:A kind of solid strong acid catalyst and the method for using it to catalyze the synthesis of 2,2-bis(2-furyl)propane

专利号:EP-3628658-A1
优先权日:2018-09-28
标 题:Synthesis of substituted enones

专利号:CN-116237066-B
优先权日:2022-12-30
标 题 :A solid strong acid catalyst and a method for catalyzing the synthesis of 2,2-di(2-furyl)propane using the same