CAS: 3572-43-8; Bromhexine

上下游产品

N-methylcyclohexylamine (2-amino-3,5-dibromophenyl)methanol 3,5-dibromo-2-amino benzaldehydeanilideN,N'-bisbenzilossicarbonilcistin-bis2,4-dibromo-6-(N-cicloesil-N-metil)aminometilanilide anilid°Carbometil-N-acetilcisteinato di metileS-2,4-dibromo-6-(N-cicloesil-N-metil)aminometilanilid°Carbometil-N-acetilcisteinato di metile anilideS-carbetossimetil-N-acetilcistein-2,4-dibromo-6-(N-cicloesil-N-metil)-aminometilanilide 22H25BrN2C22H25BrN2

2-氨基-3,5-二溴苄醇 以 四氢呋喃 用作溶剂,化学反应 6.0H,反应生成溴己新
参考文献:2-氨基-3,5-二溴苄基类中间体化合物的制备方法及其应用
标题:2-氨基-3,5-二溴苄基类中间体化合物的制备方法及其应用
摘要:本发明提供一种2‑氨基‑3,5‑二溴苄基类中间体化合物的制备方法,并进一步公开了该2‑氨基‑3,5‑二溴苄基类中间体化合物在制备溴己新和氨溴索中的应用;本发明采用廉价易得的原料2‑氨基‑3,5‑二溴苯甲醛,经还原得到2‑氨基‑3,5‑二溴苯甲醇,反应条件更加温和;用n'N‑羰基二咪唑活化2‑氨基‑3,5‑二溴苯甲醇的羟基生成活性酯,活性酯与n‑甲基环己胺和反式对氨基环己醇缩合反应分别得到相应产物;本发明公开的制备方法具有重现性好,工艺简单,产品纯度高,避免产生潜在基因毒杂质的优点,可以进一步提高2‑氨基‑3,5‑二溴苄基类化合物的用药安全.

专利信息

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-2024002331-A1
优先权日:2022-06-08
标 题 :Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
发明人：ALI MIR; BOESCH AUSTIN WAYNE; DRUMMOND DARYL CLARK; KUHLMAN WILLIAM; NIELSEN ULRIK
权利人:TIDAL THERAPEUTICS INC
摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

专利号:US-2025205169-A1
优先权日:2023-12-13
标 题:Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
发明人：ALI MIR
权利人:TIDAL THERAPEUTICS INC
摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

专利号:US-2015211039-A1
优先权日:2012-08-14
标题:Enzymes and polymerases for the synthesis of rna

专利号:WO-2014028429-A2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of rna