CAS: 3647-69-6; 4-(2-Chloroethyl)Morpholine Hydrochloride

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2-吗啉乙醇置于氯化亚砜体系中,用 氯仿 作为反应溶剂,化学反应生成 N-(2-氯乙基)吗啉盐酸盐
参考文献:侧链对叔胺官能化多肽的ph和热响应性的影响
标题:侧链对叔胺官能化多肽的ph和热响应性的影响
摘要:侧链上的ph的结构影响的系统调查和叔胺官能化聚(热响应性升-谷氨酸)s(ta-的pgs)中的溶液中进行.通过铜(i)催化的叠氮基叔胺与聚(γ-炔丙基-L-谷氨酸)(pplg)的叠氮化物-炔烃环加成点击反应有效合成了ta-Pgs聚合物.进行了比浊法测量,以表征ta-Pg在水溶液中的ph和温度诱导的相变,这表明该性质对氮的结构依赖性取代基团和1,2,3-三唑环与侧链中叔胺基团之间的"连接基".详细地讲,Ta-Pg的ph响应特性基本上由侧链中n-取代基团的疏水性决定,Ph转变点(ph T)随着n-取代基团疏水性的增加而降低,而ta Pg的温度响应性受n取代基或"连接基"的影响.具有中等n取代胺基(例如dea,Pr和pd)或支链"连接子"(例如iso-丙烯和2-甲基丙烯基)更可能表达因ph值变化而调整的lcst型相变.这项研究揭示的这些结构-属性关系将有助于开发ta-Pg在智能药物输送系统中的应用.©2013
DOI:10.1002/pola.27048

专利信息

专利号:US-2014371316-A1
优先权日:2011-11-23
标 题:Derivatives of phenoxyisobutyric acid
发明人：LALEZARI IRAJ; FABRICANT JILL S
权利人:FABRICANT JILL S; LALEZARI IRAJ
摘要:The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

专利号:WO-0144184-A1
优先权日:1999-12-16
标题:Synthesis of indole-containing spla2 inhibitors
发明人：MARTINELLI MICHAEL JOHN; SAWYER JASON SCOTT
权利人:LILLY CO ELI; MARTINELLI MICHAEL JOHN; SAWYER JASON SCOTT
摘要:A method of making a compound include reacting a compound represented by formula (I), with a base, to form the compound of formula (II); and where R1 is H, R10 or -C(O)R10; R2 is R20 -OR20, -SR20, -NR20R20' or -C(O)R20;R3, R4, R5, R6 and R7 are each individually H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R or -S(O)2R; provided that at least one of R4 and R5 is not H; each R, R10 and R20 is individually alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; each R' and R20' is individually H, alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; and W is a trisubstituted phosphorous. The method provides an alternative route to indole-3-glyoxylamide compounds.

专利号:US-6894173-B2
优先权日:1999-07-09
标 题 :Intermediates useful for synthesis of heteroaryl-substituted urea compounds, and processes of making same
发明人：ZHANG LIN-HUA; ZHU LEI
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar 1 , Ar 2 , L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

专利号:WO-0144185-A1
优先权日:1999-12-16
标题 :Carbon monoxide-based synthesis of spla2 inhibitors
发明人：SAWYER JASON SCOTT
权利人:LILLY CO ELI; SAWYER JASON SCOTT
摘要:A method of making a compound, comprises reacting a compound represented by formula (I), with CO and a catalyst, to form the compound of formula (II); where formula (I) is and, formula (II) is and where R2 is selected from the group consisting of R20 -OR20, -SR20, -NR20R20'and -C(O)R20; R3, R4, R5, R6 and R7 are each individually selected from the group consisting of H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R and -S(O)2R; provided that at least one of R4 and R5 is not H; each R and R20 is individually selected from the group consisting of alkyl, alkenyl, alkynyl, aryl and heterocyclic radical; and each R' and R20' is individually selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl and heterocyclic radical. The method provides an alternative route to indole-3-glyoxylamide compounds.

专利号:US-2009036650-A1
优先权日:2005-03-25
标 题 :Compounds and methods for peptide synthesis
发明人：CUERVO JULIO HERMAN; YANACHKOVA MILKA; PETTER RUSSELL C; DURAND-REVILLE THOMAS F; JIMENEZ-GARCIA JOSE CARLOS
权利人:CUERVO JULIO HERMAN; YANACHKOVA MILKA; PETTER RUSSELL C; DURAND-REVILLE THOMAS F; JIMENEZ-GARCIA JOSE CARLOS
摘要:A backbone nitrogen modifying group can prevent aggregation of peptides during peptide synthesis. The modifying group can promote aqueous solubility of the peptides, and be compatible with solid phase peptide synthesis. Methods for making peptides are also described.

专利号:US-2003166931-A1
优先权日:1999-07-09
标 题 :Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents