CAS: 89694-48-4; (5-Chloro-2-Methoxyphenyl)Boronic Acid

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号60633-25-2 2-溴-4-氯苯甲醚 | CAS号5720-06-9 2-甲氧基苯基硼酸 | CAS号5419-55-6 硼酸三异丙酯 | CAS号688-74-4 硼酸三丁酯 | CAS号3743-23-5 5-氯-2-甲氧基苯酚 | CAS号89488-25-5 (5-氯-2-羟基苯基)硼酸 | CAS号1261936-05-3 3-(5-chloro-2-m... | CAS号779331-28-1 5-氯-2-羟基苯基硼酸频呢醇酯 | CAS号850864-61-8 2-(2-brom°Cyclo... | CAS号90909-58-3 2-chlorobenzo[c... | CAS号62871-15-2 2-(5-chloro-2-m...

2-甲氧基苯基硼酸置于氯体系中,用 溶剂黄146 作为反应溶剂,化学反应生成 5-氯-2-甲氧基苯硼酸
参考文献:芳基硼化合物-Viii:羟基和羧苯基硼酸的一些反应
标题:芳基硼化合物-Viii:羟基和羧苯基硼酸的一些反应
摘要:羧基和羟基苯基硼酸(i-Vi)的一些新的衍生物已被制备并直接卤化邻位和对位羟基和甲氧基苯基酸进行了研究.
DOI:10.1016/s0040-4020(01)99333-0

专利信息

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-10947203-B2
优先权日:2016-03-25
标题 :1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
发明人：CHEN TAOSHENG; LIN WENWEI; WANG YUEMING
权利人:ST JUDE CHILDRENS RES HOSPITAL; ST JUDE CHILDRENS RSEARCH HOSPITAL
摘要:In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles having a structure represented by a formula: n nwhich are modulators the pregnane X receptor (“PXRâ€?); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2013134527-A1
优先权日:2012-03-07
标 题:Synthesis of polycyclic alkaloids and their use as tgr5 agonists

专利号:EP-2828263-A1
优先权日:2012-03-07
标题 :Synthesis of polycyclic alkaloids and their use as tgr5 agonists

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7671085-B2
优先权日:2002-11-15
标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof
发明人：DOWNES MICHAEL R; EVANS RONALD M
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.