CAS: 106392-12-5; Pluronic P-123

专利信息

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:US-5633260-A
优先权日:1994-04-19
标 题 :11,7 Substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
发明人：HAUSHEER FREDERICK H; HARIDAS KOCHAT
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:The novel compounds 11-hydroxy-7-ethyl camptothecin and 11-hydroxy-7-methoxy camptothecin (11,7-HECPT and 11,7-HMCPT) are active anticancer compounds which are poorly soluble in water. Because of their novelty, 11,7-HECPT and 11,7-HMCPT derivatives have not been directly administered by parenteral or oral routes to human subjects as an antitumor composition for the purpose of inhibiting the growth of cancer cells. The claimed compositions are useful as compared to the water soluble camptothecin derivatives, such as CPT-11, in clinical trials. The unpredictable interpatient variability in the metabolic production of an active metabolite from CPT-11 limits the utility of CPT-11. This invention overcomes these limitations by claiming novel pharmaceutically acceptable lactone stable formulations of 11,7-HECPT or 11,7-HMCPT, to directly administer to patients. The present invention also claims 11,7-HECPT and 11,7-HMCPT compositions, the synthesis of 11,7-HECPT or 11,7-HMCPT, the methods of formulation of 11,7-HECPT or 11,7 -HMCPT, and the methods of use of 11,7-HECPT or 11,7-HMCPT. Additionally, the claimed invention is directed to novel dosages, schedules, and routes of administration for both the 11,7-HECPT or 11,7-HMCPT formulations to humans with various forms of cancer. Other embodiments of this invention include isolation methods and methods of synthesis of certain camptothecin derivatives.

专利号:US-2024191260-A1
优先权日:2022-12-08
标题:Methods of preparing stable nucleic acid liquid formulations
发明人：WANG YING; WOOTEN HARRISON R; JACKSON CARSON
权利人:UNIV OF NORTH CAROLINA AT WILMINGTON
摘要:Stable nucleic acid liquid formulations and methods of making and using the same are provided. According to some aspects, a method for preparing stable nucleic acid liquid formulations are provided that are resistant to nucleic acid degradation caused by enzyme-independent or enzymatic hydrolysis. In some instances, stable nucleic acid liquid compositions and methods or making the same incorporate the use of at least one of a polymer and/or a salt to form a macroscopic RNA-rich condensate. In other aspects, a method for preparing stable nucleic acid encapsulated lipid nanoparticle (LNP) liquid formulations is provided that are resistant to degradation caused by nucleic acid hydrolysis, LNP leakage, and LNP aggregation. In some instances, stable nucleic acid liquid compositions and methods or making the same incorporate the use of a pair of thermodynamically matching LNP synthesis buffer and LNP product formulation buffer with close-to-equal osmotic pressure and chemical potentials of solution components.

专利号:US-9867899-B2
优先权日:2010-05-24
标题 :Reinforced adhesive complex coacervates and methods of making and using thereof
发明人：STEWART RUSSELL J
权利人:UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices. In particular, the reinforced adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, wet tissues in physiological conditions.

专利号:US-2014220082-A1
优先权日:2011-06-28
标 题:Adhesive complex coacervates and methods of making and using thereof
发明人：STEWART RUSSELL J
权利人:STEWART RUSSELL J; UNIV UTAH RES FOUND
摘要:Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are produced by reacting (a) at least one poly anion comprising a plurality of activated ester groups, and (b) at least one polycation comprising a plurality of nucleophilic groups, wherein the nucleophilic groups react with the activated ester groups to produce a new oovalent bond between the polycation and the polyanion. The adhesive complex coacervates described herein have low interfacial tension with water and wettable substrates. When applied to a wet substrate they spread over the interface rather than beading up. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in wet or underwater applications and situations where water is present such as, for example, physiological conditions.

专利号:US-2019055337-A1
优先权日:2016-02-02
标题 :Low-cost synthesis of macromonomers
发明人：MAYS JIMMY W; KANG NAM-GOO; WANG WEIYU; WANG HUIQUN
权利人:UNIV TENNESSEE RES FOUND
摘要:Methods of preparing macromonomers, e.g., single- or double-tailed macromonomers, using radical polymerization of a first monomer in solution or in an emulsion are described. Methods of using the macromonomers in the preparation of multigraft copolymers are also described. For instance, the macromonomer prepared by radical polymerization can be used in an emulsion copolymerization with a second monomer to form a random multigraft copolymer. The random multigraft co-polymers can be superelastomers.