CAS: 114873-01-7; Boc-Phe(3-F)-Oh

相似化合物

114873-11-9 87184-23-4 198545-72-1

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号19883-77-3 3-氟-L-苯丙氨酸 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈

二碳酸二叔丁酯置于sodium Carbonate,三乙胺体系中,用 水,乙腈 用作溶剂,化学反应 17.0H,反应生成Boc-L-3-氟苯丙氨酸
参考文献:一种用于将 Boc 保护基团引入胺类的新试剂:Boc-Oasud
标题:一种用于将 Boc 保护基团引入胺类的新试剂:Boc-Oasud
摘要:摘要描述了一种用于制备 N-Boc-氨基酸的新试剂叔丁基 (2,4-Dioxo-3-Azaspiro [5,5] Undecan-3-yl) 碳酸酯 (Boc-Oasud).Boc-Oasud 在室温下在碱存在下与氨基酸及其酯反应,并以非常好的收率和纯度得到 N-Boc-氨基酸及其酯.Boc 基团的引入无需外消旋化.Boc-Oasud 是一种固体且更稳定,是二碳酸二叔丁酯的更好替代品,二碳酸二叔丁酯熔点低,由于稳定性差,必须在塑料容器中分配,而不是玻璃.图形概要
Doi:10.1080/00397911.2017.1366525

专利信息

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.