对苯二甲醚置于benzyltrimethylazanium Tetrachloro-λ3-Iodanuide体系中,用 溶剂黄146 用作溶剂,化学反应 1.0H,以38%的收率获得地茂散 参考文献:Halogenated Volatiles From The Fungus Geniculosporium And The Actinomycete Streptomyces Chartreusis 标题:Halogenated Volatiles From The Fungus Geniculosporium And The Actinomycete Streptomyces Chartreusis 摘要:在真菌geniculosporium的头空间提取物中检测到了两种未经鉴定的氯化挥发性化合物x和y.它们的质谱指向x为氯二甲氧基苯,Y为二氯二甲氧基苯的结构.X和y的一些构造异构体的质谱已包含在我们的数据库中,证明它们非常相似,因此无法完全确定结构.为了明确结构,我们通过合成或从商业供应商处获得了x和y的所有可能的构造异构体.质谱和气相色谱保留时间的比较严格确定了这两种氯化挥发性化合物的结构.氯化挥发性化合物并不是很常见,但溴化或甚至碘化的挥发性化合物更为罕见.令人惊讶的是,从streptomyces Chartreusis的头空间提取物中发现了甲基2-碘苯甲酸酯,这是一种新的天然产物,丰富了碘化天然产物家族. Doi:10.3762/bjoc.9.311
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-9968097-B2 优先权日:2012-05-30 标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction 发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND 权利人:BAYER CROPSCIENCE AG 摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
专利号:WO-2021074309-A1 优先权日:2019-10-16 标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)
专利号:WO-2021074311-A1 优先权日:2019-10-16 标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)
专利号:US-8937089-B2 优先权日:2004-07-01 标 题:Synergistic mixtures of anthranilamide invertebrate pest control agents 发明人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN 权利人:ANNAN ISAAC BILLY; FLEXNER JOHN LINDSEY; PORTILLO HECTOR EDUARDO; LAHM GEORGE PHILIP; SELBY THOMAS PAUL; STEVENSON THOMAS MARTIN; DU PONT 摘要:Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof n n n n n n n n n n n n andn na component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.n n n n n n Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.
[参考文献]: E K Frederick, Et Al. Degradation Of Chloroneb, Triadimefon, And Vinclozolin In Soil, Thatch, And Grass Clippings. Bull Environ Contam Toxicol. 1994 Oct;53(4):536-42. [参考文献]: H M Müller, Et Al. [参考文献]: Acta Histochem Suppl. 1984:30:347-51. [参考文献]: Jhonyson Arruda Carvalho Guedes, Et Al. Matrix Effect In Guava Multiresidue Analysis By Quechers Method And Gas Chromatography Coupled To Quadrupole Mass Spectrometry. Food Chem. 2016 May 15:199:380-6. [参考文献]: M A Ramesh, Et Al. The Camp Signal Transduction Pathway Mediates Resistance To Dicarboximide And Aromatic Hydrocarbon Fungicides In Ustilago Maydis. Fungal Genet Biol. 2001 Apr;32(3):183-93. [参考文献]: N M Martinez-Rossi, Et Al. Two-Way Selection Of Mutants And Revertants To Chloroneb Resistance In Aspergillus Nidulans. Mutat Res. 1982 Sep;96(1):31-9.
合成参考文献
摘要:Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-317 摘要:Galadi A et al; Chemosphere 30: 1655-69 (1995) 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:IATA. Dangerous Goods Regulations. 45 th Ed. Montreal, Canada and Geneva, Switzerland. International Air Transport Association. Dangerous Goods Regulations, 2004., p. 208 摘要:Association of American Railroads/Bureau of Explosives; Emergency Handling of Hazardous Materials in Surface Transportation. Association of American Railroads. Pueblo, CO. 2002., p. 695