CAS: 4301-14-8; Ethynylmagnesium Bromide

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CAS号925-90-6 乙基溴化镁 | CAS号74-86-2 乙炔 | CAS号106-96-7 溴代丙炔 | CAS号4301-15-9 acetylene-bis-m... | CAS号100-58-3 苯基溴化镁 | CAS号75-16-1 甲基溴化镁 | CAS号108277-05-0 Thiepane, 2-eth... | CAS号1112-00-1 ethynyl(trimeth... | CAS号3230-69-1 3-甲基-1-戊烯-4-炔-3-醇 | CAS号565-68-4 4-甲基-1-戊炔-3-醇 | CAS号5396-61-2 3-乙基-1-庚炔-3-醇 | CAS号4717-40-2 17-乙炔基雌三醇 | CAS号471-25-0 丙炔酸 | CAS号3623-15-2 1-苯基-2-丙炔-1-酮 | CAS号15071-66-6 1-Methyl Ethyny... | CAS号14519-31-4 1-ETHYNYL-CYCLO...

3-溴丙炔置于magnesium,Mercury Dichloride体系中,用 乙醚,甲苯 作为反应溶剂,化学反应 0.75H,反应生成 乙炔基溴化镁
参考文献:Use Of Propargyl Glycine Amino Propargyl Diol Compounds For Inhibiting Plasma Renin Activity
标题:Use Of Propargyl Glycine Amino Propargyl Diol Compounds For Inhibiting Plasma Renin Activity
摘要:通常被描述为丙炔基甘氨酸氨基丙炔二醇衍生物的化合物,可用于治疗通过抑制血浆肾素活性介导的疾病.特别感兴趣的化合物是符合以下式i的化合物 其中a从co和so2中选择,X从氧原子和亚甲基中选择;r1和r9中的每一个独立选择自氢,甲基,乙基,正丙基,异丙基,苄基,三氟乙基,叔丁氧羰基和甲氧甲基羰基的基团,R1和r9附着的氮原子可以与氧结合形成n-氧化物;r2从氢,甲基,乙基和异丙基中选择;r3从苄基,环己基甲基,苯乙基,咪唑基甲基,吡啶基甲基和2-吡啶基乙基中选择;r5和r8中的每一个独立地是丙炔基或含丙炔基的基团;r7是环己基甲基;r4和r6中的每一个独立选择自氢和甲基;r11和r12中的每一个独立选择自氢,烷基和苯基;m为零;n为从零到三中选择的数字;或其药用可接受盐.

专利信息

专利号:US-5705659-A
优先权日:1994-09-30
标 题 :Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof
发明人：PARK HOKOON; JUNG SUN HO; LEE YONG SUP; NAM KI HONG
权利人:KOREA INST SCI & TECH
摘要:Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, t-butyldimethylsilyl, triisopropylsilyl or triethylsilyl group; R 1 and R 2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epi-stereoisomeric mixture.

专利号:US-3996255-A
优先权日:1974-04-24
标题 :Total synthesis of 11-deoxy-15-substituted prostaglandins
发明人：STRIKE DONALD P; KAO WENLING
权利人:AMERICAN HOME PROD
摘要:Processes for the total synthesis of dl-11-deoxy-15-substituted prostaglandins, novel intermediates therefore, certain novel final products, as well as optical resolutions of the final products are disclosed.

专利号:US-5434281-A
优先权日:1993-06-01
标 题 :Process for the stereospecific synthesis of leukotriene B4 in its 6Z, 8E, 10E configuration and intermediates
发明人：SOLLADIE GUY; STONE GUY; URBANO-PUJOL ANTONIO; MAIGNAN JEAN
权利人:OREAL
摘要:Process for the stereospecific synthesis of leukotriene B 4 (LTB 4 ) of 6Z, 8E, 10E configuration of formula ##STR1## in which a dibenzoate triether is prepared which is subjected to a reductive elimination according to the diagram ##STR2## so as to obtain a triether which is converted in order to obtain the leukotriene B 4 .

专利号:US-7605218-B2
优先权日:2004-02-03
标题:Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions
发明人：KELLER TEDDY M; KOLEL-VEETIL MANOJ K
权利人:US NAVY
摘要:A carborane-siloxane compound is provided having the repeat unit n nQ contains any of —SiR 2 —, —SiR 2 —O—, —C≡C—C≡C—, carboranyl, and U′. Each R and R′ is alkyl, aryl, alkylaryl, haloalkyl, haloaryl, or mixtures thereof. Each U′ is derivable from hydrosilation of an alkenyl or alkynyl group. Each T is alkyl, aryl, alkylaryl, haloalkyl, haloaryl mixtures thereof, —(O—SiR′ 2 ) x H, or the repeat unit. Each x and x′ is a positive integer. The compounds may be made be reacting a carborane-siloxane precursor having unsaturated end groups with a siloxane crosslinker in the presence of a hydrosilation catalyst.

专利号:US-9969686-B2
优先权日:2014-08-05
标 题 :Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; LI XIAOXUN; SHU DONGXU; WINSTON-MCPHERSON GABRIELLE N
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.

专利号:US-8822733-B2
优先权日:2011-02-16
标题 :Intermediates for the preparation of beta-santalol
发明人：CHAPUIS CHRISTIAN
权利人:CHAPUIS CHRISTIAN; FIRMENICH & CIE
摘要:The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein the dotted line may represents an additional bond and R a represents a hydrogen atom or a Si(R b ) 3 or (R b ) 2 COH group, each R b representing C 1-6 alkyl group or a phenyl group. The invention concerns also the compound (I) as well as its use for the synthesis of β-santalol or of derivatives thereof.