CAS: 6961-82-6; O-Chlorobenzenesulfonamide

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CAS号2905-23-9 2-氯苯磺酰氯 | CAS号1336-21-6 氨水 | CAS号64902-72-3 氯磺隆 | CAS号64900-65-8 邻氯苯磺酰基异氰酸酯 | CAS号17315-42-3 (CH3)3SnC6H4-o-Cl | CAS号95-51-2 2-氯苯胺 | CAS号105985-17-9 3-氯吡嗪-2(1H)-酮 | CAS号3306-62-5 2-氨基苯磺酰胺 | CAS号3320-83-0 2-氯苯基异氰酸酯 | CAS号143105-07-1 N-(2-chlorophen... | CAS号64900-65-8 邻氯苯磺酰基异氰酸酯 | CAS号135594-19-3 1-(2-chlorophen... | CAS号111248-89-6 1,3-二氢-2,1-苯并异噻... | CAS号84108-97-4 3-propan-2-yl-1... | CAS号90096-45-0 ethyl N-(2-chlo...

氯磺隆置于盐酸体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 邻氯苯磺酰胺
参考文献:Kinetics And Hydrolysis Mechanism Of Chlorsulfuron And Metsulfuron-Methyl
标题:Kinetics And Hydrolysis Mechanism Of Chlorsulfuron And Metsulfuron-Methyl
摘要:Abstractin Acidic Media,Hydrolysis Of Chlorsulfuron And Metsulfuron‐methyl occurs Via Two Consecutive Reactions Which Were Followed By Ultraviolet Spectrophotometry. For These Two Reactions,The Pseudo‐first‐order Rate Constants Increase Proportionally To The Concentration Of Hydronium Ion In The More Acidic Media And To The Square Of This Concentration At Higher Ph Values.A Kinetic Study By HPLC Shows That The First Reaction Leads To The Formation Of 4‐methoxy‐6‐methyl‐1,3,5‐triazin‐2‐amine And (O‐chlorophenylsulfonyl) Carbamic Acid For Chlorsulfuron Or (O‐methoxycarbonylphenylsulfonyl) Carbamic Acid For Metsulfuronmethyl. The Second Reaction Is The Conversion Of These Sulfonylcarbamic Acids To Sulfonamides And Carbon Dioxide. The Complete Lack Of Saccharin And Of O‐sulfamoyl Benzoic Acid Proves That The Ester Function Of The Methoxycarbonyl Group Is Stable.The Lack Of General Acid‐base Catalysis And A Solvent Deuterium Isotope Effect Less Than Unity Are Consistent With A Rate‐determining Cleavage Of The Protonated Substrate.In The Basic Ph Range (10-14) A Single Reaction occurs,The Nucleophilic Substitution Of The Methoxy Group On The Triazine By A Hydroxide Group.
DOI:10.1002/ps.2780400112

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-9013609-A1
优先权日:1989-05-01
标题 :Novel fluorescent pigment compositions and a process for their preparation and use of same
发明人：MALLAVARAPU LEO X
权利人:MALLAVARAPU LEO X
摘要:A process is disclosed for producing novel fluorescent pigment compositions with no formaldehyde or para-formaldehyde during their synthesis. The synthesis of these compositions is, for example, achieved by using an in situ reaction of epoxy resins of preferably up to a molecular weight of 20,000 with a sulfonamide compound, e.g., toluene sulfonamide, in the presence of a Lewis acid catalyst, followed by, preferably, the further reaction with an isocyanate, e.g., aliphatic isocyanate and/or para-toluene sulfonyl isocyanate. During this reaction, a fluorescent dye is incorporated into the molten mass.

专利号:US-3839325-A
优先权日:1973-03-23
标题:Synthesis of 4-sulfonamidophenyl hydrazines
发明人：HOFFSTADT W
权利人:GAF CORP
摘要:A synthesis is disclosed utilizing p-chlorobenzene-sulfonamide compounds of the following formula: IN WHICH R and R1 independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl, alkaryl, aralkyl or aryl, which may or may not be further substituted, or together with the nitrogen atom form a heterocyclic ring. These compounds are dissolved in dimethyl sulfoxide (DMSO), mixed with aqueous hydrazine hydrate and heated until completely reacted to form 4 - sulfonamidophenyl hydrazines that can be readily separated from the reaction media by precipitation with water. The precipitate can be readily washed and dried to provide a pure, substituted sulfonamido hydrazine. The product is obtained in high yields frequently of about 80 - 90 percent and is sufficiently pure for subsequent use in the preparation of substituted phenyl pyrazolones which in turn are useful as magenta color formers in color photography. For example, p-chloro-benzene-sulfonyl morpholine is dissolved in DMSO and reacted under reflux conditions with aqueous hydrazine hydrate to form 4 - morpholino - sulfonamido-phenyl hydrazine having a melting point of 162*- 164*C after purification.

专利号:US-9422244-B2
优先权日:2010-01-29
标 题 :Synthesis of substituted pyrazoline carboxamidine derivatives
发明人：VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P
权利人:VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P; ABBVIE BAHAMAS LTD
摘要:This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.

专利号:US-3857834-A
优先权日:1968-03-07
标 题 :Reagents for aldehyde synthesis
发明人：NAGATA W; HAYASE Y
权利人:SHIONOGI & CO
摘要:WHEREIN R4 has the same meaning as described above. WHEREIN R1 represents a lower alkyl group, R2 represents R1O or an alkyl, aralkyl or aryl group, R3 represents an acyclic or cyclic alkyl or aryl group, and R4 represents a hydrogen atom, an alkyl, aralkyl or alkoxycarbonyl group or a halogen atom, which react with carbonyl compounds Reagents for aldehyde synthesis, particularly for formylolefination, of the general formula:

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same