CAS: 725-89-3; 3,5-Bis(Trifluoromethyl)Benzoic Acid

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CAS号124-38-9 二氧化碳 | CAS号328-70-1 1,3-双(三氟甲基)-5-溴苯 | CAS号401-96-7 3,5-bis-trifluo... | CAS号402-31-3 间二三氟甲苯 | CAS号729-81-7 1,3,5-三(三氟甲基)苯 | CAS号32707-89-4 3,5-二(三氟甲基)苯甲醇 | CAS号174083-39-7 3,5-双三氟甲基苯乙酰氯 | CAS号402-31-3 间二三氟甲苯 | CAS号401-95-6 3,5-双(三氟甲基)苯甲醛 | CAS号30071-93-3 3,5-双(三氟甲基)苯乙酮 | CAS号85068-33-3 3,5-双(三氟甲基)苯乙酸 | CAS号785-56-8 3,5-双(三氟甲基)苯甲酰氯 | CAS号131805-94-2 1-(3,5-双(三氟甲基)苯... | CAS号26107-82-4 3,5-二(三氟甲基)苯-1-碳酰肼

间二三氟甲苯置于1,3-二溴-5,5-二甲基海因,硫酸,异丙基氯化镁体系中,用 四氢呋喃,溶剂黄146 作为反应溶剂,-45.0~45.0 °C,137.9 Kpa 条件下,反应 6.0H,反应生成 3,5-双三氟甲基苯甲酸
参考文献:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
标题:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
摘要:开发了一种改进的高效溴化3,5-双(三氟甲基)苯.描述了从前体溴化物安全可靠地制备潜在爆炸性的3,5-双(三氟甲基)苯基格氏试剂和3-三氟甲基苯基格氏试剂的方法.反应系统筛选工具(rsst)和差热分析(dta)研究表明,这些三氟甲基苯基格氏试剂可在失去溶剂接触或适度加热的情况下爆炸.当按照本文所述的方法制备和处理时,这些格氏试剂可以安全地制备并用于高级中间体.
DOI:10.1021/jo026903N

专利信息

专利号:US-6350915-B1
优先权日:1999-06-11
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-6489507-B1
优先权日:1999-06-11
标题:Process for the synthesis of 3,5-bis(trifluoromethyl)benzoic acid
发明人：CVETOVICH RAYMOND; LEAZER JOHN
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)benzoic acid (CAS 725-89-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.

专利号:US-6814895-B2
优先权日:2000-12-20
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND; ASAI TOMOYUKI; YODOGAWA YOSHIKO
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-9981935-B2
优先权日:2013-07-05
标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
发明人：MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-2024067674-A1
优先权日:2020-12-28
标 题 :Method for loading amino acid on resin for solid-phase synthesis
发明人：SEKITA HIROKO; KOMIYA SHIO; DAN KATSUNORI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a peptide compound of high purity at a high yield. It was found that an amino acid can be efficiently loaded on a resin for solid-phase synthesis by bringing an amino acid solution containing a specific solvent into contact with a resin for solid-phase synthesis that has been swollen with a specific solvent, thereby solving such problem.