CAS: 868241-48-9; 2,2-Difluoropropan-1-Amine Hydrochloride

该化合物是一种多用途有机化合物,以其稳定性和高纯度而著称,其独特的氟化结构增强了其在各种有机溶剂中的溶解性,使它更适合化学合成.该化合物与各种试剂的兼容性及其形成稳定的矿产品衍生物的能力有助于其在制药和精细化学应用中的广泛使用.

英文名称2,2-Difluoropropan-1-Amine Hydrochloride
中文名称2,2-二氟丙胺盐酸盐
IUPAC名称2,2-difluoropropan-1-amine hydrochloride
其它别名2,2-二氟-1-丙胺盐酸盐; 2,2-Difluoropropan-1-Amine Hcl
CAS编号868241-48-9
MFCD编号:MFCD06659051
EINECS号:639-411-0
分子式:C3H8ClF2N
分子量:131.55
产品CID: 1871334
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
InChIKey: IDJKGOWDPKVIBR-UHFFFAOYSA-N
InChI=1S/C3H7F2N.ClH/c1-3(4,5)2-6;/h2,6H2,1H3;1H…
计算化学: 氢键受体数1.0氢键供体数1可旋转键数1

相似化合物

49781-48-8 133186-53-5 79667-91-7

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

ECHA物质C&L通报

合成工艺路线路线简述

1017241-19-8 = 868241-48-9
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 48 H,Reflux
标题:Discovery Of 2-(2-Chlorophenyl)-3-(4-Chlorophenyl)-7-(2,2-Difluoropropyl)-6,7-Dihydro-2H-Pyrazolo[3,4-F][1,4]Oxazepin-8(5H)-One (Pf-514273),A Novel,Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist For The Treatment Of Obesity
作者:Dow,Robert L.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(9) 页码:2652-2655]

2450-71-7 = 868241-48-9
反应条件:1.1 Reagents: Hydrofluoric Acid,Antimony Pentafluoride; 2 H,-40 °C1.2 Reagents: Sodium Carbonate Solvents: Water; Neutralized,Cooled1.3 Reagents: Hydrochloric Acid Solvents: Methanol
标题:Gem-Difluorination Of Aminoalkynes Via Highly Reactive Dicationic Species In Superacid Hf-Sbf5: Application To The Efficient Synthesis Of Difluorinated Cinchona Alkaloid Derivatives
作者:Cantet,Anne-Celine; Et Al
参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(7) 页码:2875-2878]

3416-57-7 = 868241-48-9
反应条件:1.1 Reagents: (Diethylamino)Sulfur Trifluoride; 66 H,Rt2.1 Reagents: Hydrochloric Acid Solvents: Water; 48 H,Reflux
标题:Discovery Of 2-(2-Chlorophenyl)-3-(4-Chlorophenyl)-7-(2,2-Difluoropropyl)-6,7-Dihydro-2H-Pyrazolo[3,4-F][1,4]Oxazepin-8(5H)-One (Pf-514273),A Novel,Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist For The Treatment Of Obesity
作者:Dow,Robert L.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(9) 页码:2652-2655]

1074-82-4 = 868241-48-9
反应条件:1.1 Solvents: Toluene; 18 H,100 °C2.1 Reagents: (Diethylamino)Sulfur Trifluoride; 66 H,Rt3.1 Reagents: Hydrochloric Acid Solvents: Water; 48 H,Reflux
标题:Discovery Of 2-(2-Chlorophenyl)-3-(4-Chlorophenyl)-7-(2,2-Difluoropropyl)-6,7-Dihydro-2H-Pyrazolo[3,4-F][1,4]Oxazepin-8(5H)-One (Pf-514273),A Novel,Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist For The Treatment Of Obesity
作者:Dow,Robert L.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(9) 页码:2652-2655

2-(2,2-二氟丙基)异吲哚-1,3-二酮置于盐酸体系中,用水作为反应溶剂,化学反应 48.0H,以20 G的收率获得产物2,2-二氟丙胺盐酸盐
参考文献:Discovery Of 2-(2-Chlorophenyl)-3-(4-Chlorophenyl)-7-(2,2-Difluoropropyl)-6,7-Dihydro-2H-Pyrazolo[3,4-F][1,4]Oxazepin-8(5H)-One (Pf-514273),A Novel,Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist For The Treatment Of Obesity
标题:Discovery Of 2-(2-Chlorophenyl)-3-(4-Chlorophenyl)-7-(2,2-Difluoropropyl)-6,7-Dihydro-2H-Pyrazolo[3,4-F][1,4]Oxazepin-8(5H)-One (Pf-514273),A Novel,Bicyclic Lactam-Based Cannabinoid-1 Receptor Antagonist For The Treatment Of Obesity
摘要:We Report The Design,Synthesis,And Structure-Activity Relationships Of Novel Bicyclic Lactam-Based Cannabinoid Type 1 (Cb,) Receptor Antagonists. Members Of These Series Are Potent,Selective Antagonists In In Vitro/in Vivo Efficacy Models Of Cb,Antagonism And Exhibit Robust Oral Activity In Rodent Models Of Food Intake. These Efforts Led To The Identification Of 19D,Which Has Been Advanced To Human Clinical Trials For Weight Management.
DOI:10.1021/jm900255T