CAS: 101-94-0; (4-Methylphenyl) 2-Phenylacetate

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CAS号103-82-2 苯乙酸 | CAS号106-44-5 对甲酚 | CAS号103-80-0 苯乙酰氯 | CAS号14643-62-0 tris(p-methylph... | CAS号1555-80-2 Benzeneacetic a... | CAS号2491-34-1 Ethanone,1-(2-h... | CAS号946-80-5 苄基苯基醚 | CAS号103-29-7 1, 2-二苯乙烷 | CAS号108-95-2 苯酚 | CAS号24258-63-7 1-(2-羟基-5-甲基苯基)... | CAS号7500-45-0 N-benzyl-2-phen... | CAS号64075-36-1 N-丙基-苯乙酰胺

苯乙酰氯置于4-二甲氨基吡啶,Sodium Sulfide,四丁基溴化铵,三乙胺体系中,用 二氯甲烷,水,甲苯 用作溶剂,化学反应 3.0H,反应生成苯乙酸对甲酚酯
参考文献:二酰基二硫化物:4-(n,N-二甲基氨基)吡啶催化的苯酚化学选择性酰化试剂
标题:二酰基二硫化物:4-(n,N-二甲基氨基)吡啶催化的苯酚化学选择性酰化试剂
摘要:为了通过dmap(4-(n,N-二甲基氨基)吡啶)催化实现有效的酯形成,发现了通用且优异的酰化试剂二酰基二硫化物.该方案为酚和伯脂族羟基的位点选择性酰化提供了一个有希望的合成平台,这大大扩展了保护基化学的领域.该试剂的重要性还体现在其出色的耐湿性,高效率以及在合成化学和生物学上有意义的天然产物修饰方面的潜力.
Doi:10.1021/acs.Orglett.6B02818

专利信息

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-2010137244-A1
优先权日:2006-07-13
标题 :Preparation and utility of hmg-coa reductase inhibitors
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.

专利号:US-2019127396-A1
优先权日:2017-11-01
标题 :Synthesis of boronate ester derivatives and uses thereof