CAS: 1226781-44-7; (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-(Methylsulfonyl)-2,6-Dihydropyrrolo[3,4-C]Pyrazol-5(4H)-yl)Tetrahydro-2H-Pyran-3-Amine

上下游产品

CAS号1226781-87-8 tert-butyl {(2R... | CAS号1280210-80-1 2,4,5,6-四氢-2-(甲... | CAS号6573-19-9 2,4,5,6-四氢吡咯并[3... | CAS号657428-42-7 4,6-二氢-1H-吡咯[3,... | CAS号2646-90-4 2,5-二氟苯甲醛

2,5-二氟溴苯置于三乙基硅烷,Lithium Aluminium Tetrahydride,正丁基锂,硫酸,Palladium 10% On Activated Carbon,三氟化硼乙醚,盐酸羟胺,四丁基氟化铵,氢气,Sodium Methylate,Sodium Acetate,戴斯-马丁氧化剂,溶剂黄146,三乙胺,三氟乙酸,[双(三氟乙酰氧基)碘]苯体系中,用 四氢呋喃,甲醇,乙醚,正己烷,二氯甲烷,水,丙酮,乙腈 用作溶剂,化学反应 24.5H,反应生成奥格列汀
参考文献:手性四氢吡喃衍生物及其制备与用途
标题:手性四氢吡喃衍生物及其制备与用途
摘要:本发明公开了一种式22所示的化合物,其中,R选自被卤素,C1‑c3烷基,C2‑c3链烯基中的一种或多种所取代的五到六元芳基,含1‑2个硫原子的五到六元杂芳基,被c1‑c3烷硫基取代的c1‑c3烷基或含1‑2个硫原子的5‑6元环烷基.本发明还公开了其制备方法及用途.其可实现多种新型四氢吡喃手性衍生物的合成,不涉及贵金属催化剂等原料,降低成本.

专利信息

专利号:US-9481680-B2
优先权日:2014-03-20
标题 :Process for the preparation of key intermediates of omarigliptin
发明人：DE LUCCHI OTTORINO; ROSSO ENRICO; ZARAMELLA SIMONE; TARTAGGIA STEFANO
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) n nwherein R 1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV)n n nby an amination reaction to a compound of formula (III),n n nwhich is then protected to provide a compound of formula (II),n n nwhich is then alkylated to provide the compound of formula (I).

专利号:US-9527855-B2
优先权日:2011-06-29
标题:Process for preparing chiral dipeptidyl peptidase-IV inhibitors
发明人：ZACUTO MICHAEL J; DUNN ROBERT F; MOMENT AARON J; JANEY JACOB M; LIEBERMAN DAVID; SHEEN FAYE; BREMEYER NADINE; SCOTT JEREMY; KUETHE JEFFREY T; TAN LUSHI; CHEN QINGHAO
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME
摘要:A process for the preparation of pyrazolopyrolidines of structural formula I: n nand W isn n nor P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

专利号:CN-107382929-A
优先权日:2017-07-21
标题 :Application of the enzyme technology in the synthesis of Ao Gelieting intermediates

专利号:CN-107253940-A
优先权日:2017-07-21
标题 :Application of the asymmetric o conjugate addition reactions in the synthesis of Ao Gelieting intermediates

专利号:CN-111793071-A
优先权日:2020-07-06
标 题:The synthesis process of alogliptin