CAS: 127264-14-6; 5-(2-Bromoethyl)-2,3-Dihydrobenzofuran

上下游产品

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 1-(2,3-dihydrobenzofuran-5-yl)ethanone 2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one (S)-darifenacin hydrobromide darifenacin 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]°Ctane formate

2,3-二氢苯并呋喃置于aluminum (III) Chloride,Sodium Tetrahydroborate,三氟化硼乙醚,三溴化磷体系中,用 四氢呋喃,二氯甲烷,氯仿 用作溶剂,化学反应 5.0H,反应生成5-(2-溴乙基)-2,3-二氢苯并呋喃
参考文献:达非那新中间体2,3-二氢-5-苯并呋喃乙酸的 制备新方法
标题:达非那新中间体2,3-二氢-5-苯并呋喃乙酸的 制备新方法
摘要:本发明涉及一种达非那新中间体--2,3‑二氢‑5‑苯并呋喃乙酸的制备新方法.在路易斯酸的作用下,由2,3‑二氢苯并呋喃为起始原料,和草酰氯单乙酯经由friedel‑crafts酰基化反应得到相应的酰基化合物;经水解后得到α‑酮酸钠盐;再利用wolff‑kishner‑黄鸣龙反应,将羰基还原成亚甲基,经酸化得到2,3‑二氢‑5‑苯并呋喃乙酸.本发明的方法简便而安全,各反应原料价廉易得,反应收率高,尤其适于工业化生产2,3‑二氢‑5‑苯并呋喃乙酸.

专利信息

专利号:US-5302595-A
优先权日:1988-10-04
标题:Muscarinic receptor antagonists
发明人：CROSS PETER E; MACKENZIE ALEXANDER R
权利人:PFIZER
摘要:Compounds of the formula I ##STR1## wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

专利号:US-9518067-B2
优先权日:2013-03-27
标题 :Trifluoroborate mass spectrometric tags
发明人：HUANG YUMEI
权利人:CELLMOSAIC INC
摘要:The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF 3 ) molecules, transferring the negative charge to the rest of the molecule. Such a fragmentation pattern is used to detect and quantitate analytes of interest after derivatization with organo-trifluoroborates.

专利号:CN-102731449-A
优先权日:2011-04-01
标题 :A kind of synthesis technology of dalfinacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran

专利号:CN-102731449-B
优先权日:2011-04-01
标 题 :A kind of synthesis technology of dalfinacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran