CAS: 144284-25-3; 2,4,5-Trifluorobenzyl Alcohol

上下游产品

2,4,5-trifluorobenzaldehyde ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-(2 4 5-trifluorophenyl)nona-2 4 6 8-tetraenoate (2E,4E,6E,8E)-3,7-dimethyl-9-(2,4,5-trifluorophenyl)nona-2,4,6,8-tetraenoic acid triphenyl(2,4,5-trifluorobenzyl)phosphonium bromide (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid

2,4,5-三氟苯甲醛置于sodium Tetrahydroborate,水体系中,用 乙腈 用作溶剂,化学反应生成2,4,5-三氟苯甲醇
参考文献:Electrophilicity And Nucleophilicity Of Commonly Used Aldehydes
标题:Electrophilicity And Nucleophilicity Of Commonly Used Aldehydes
摘要:目前用于确定醛类电亲和性(E)和核亲和性(N)的方法包括对kmno4氧化和nabh4还原醛类的动力学研究.对kmno4促进的醛氧化反应的过渡态分析表明,其与实验结果具有非常好的相关性.通过两种反应的实验活化参数验证了实验方法的有效性.通过理论与实验关系的进一步证明,该方法为各种醛类提供了便捷获取e和n值的途径,并能直观评估醛类在不同反应中的化学反应性.
Doi:10.1039/c4Ob00555D

专利信息

专利号:US-8765668-B2
优先权日:2010-06-04
标 题 :Methods of synthesis of β-aminobutyryl substituted compounds
发明人：STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO
权利人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO; LEK PHARMACEUTICALS
摘要:The present invention relates to process to prepare β-aminobutyryl compounds having β-amino acid core structural moieties and optionally having γ-phenyl and/or heterocyclic structural moieties. Such compounds are useful as key structure framework of modern drug chemistry.