CAS: 20491-53-6; Di(Propan-2-yl)Phosphane

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2-iodo-propane di(tert-butyl)chlorophosphine isopropylmagnesium chloride 1,1-dibutoxy-2,2-diisopropyl-diphosphanetris(1-methylethyl)phosphine Acetyl-di-(isopropyl)-phosphin Hexafluorisobutyroyl-di-(isopropyl)-phosphin Di-isopropyl-N-phenylcarbamylphosphin

Methyl Diisopropylphosphinate置于二异丁基氢化铝体系中,用 乙醚 用作溶剂,化学反应 4.5H,以0.772 G的收率获得二异丙基磷化氢
参考文献:一级,二级和三级膦的革兰氏级合成的通用方法
标题:一级,二级和三级膦的革兰氏级合成的通用方法
摘要:尽管有机膦的合成在一个世纪的上半叶已广为人知,但是即使对于资深的合成化学家来说,膦的合成仍然代表着艰巨的任务.膦作为一类化合物,其对空气的敏感性差异很大,并且误以为新手化学家尝试看似简单的合成是微不足道的,甚至是容易的,这会带来灾难性的结果.为了简化任务,我们之前已经开发出一种使用台式中间体访问各种氧化膦(膦的直接前体)的方法.这种合成方法可以节省无空气的处理,直到最后一步(还原并分离出膦).本文介绍了将膦酸酯,次膦酸酯和膦氧化物轻松还原为伯,仲,和叔膦使用氢化铝还原剂.亲电还原剂(i Bu) 2 Alh和alh 3在还原选择性和反应性方面被确定大大优于lialh 4.值得注意的是,即使lialh 4和( I Bu) 2 Alh不能,Alh 3仍能还原具有极强抗性的三环己基氧化膦.使用这种新方法,可以以克级反应合成出代表性范围的伯,仲和叔膦(包括挥发性膦),而无需纯化步骤,可实现出色的收率和无与伦比的纯度.
Doi:10.1021/acs.Organomet.7B00684

专利信息

专利号:US-8716507-B2
优先权日:2008-10-31
标题 :Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis
发明人：MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA
权利人:MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA; GOVERNING COUNCIL OF UNIVERSITY OF TORONTO
摘要:New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts.

专利号:US-9045381-B2
优先权日:2010-10-19
标 题:Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof
发明人：MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING
权利人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING; YEDA RES & DEV
摘要:The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

专利号:CN-102439025-B
优先权日:2008-09-06
标题:RNA Synthesis - Phosphoramidites for reverse synthesis of RNA, and applications in the convenient introduction of ligands, chromophores and modifiers for RNA synthesis at the 3'-end

专利号:US-7541143-B2
优先权日:1997-02-20
标题 :Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
发明人：PACKARD BEVERLY; KOMORIYA AKIRA
权利人:ONCOIMMUNIN INC
摘要:The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid, polypeptide, etc.) joining two fluorophores of the same species whereby the fluorophores form an H-dimer resulting in quenching of the fluorescence of the fluorophores. When the backbone is cleaved or changes conformation, the fluorophores are separated, no longer forming an H-type dimer, and are de-quenched thereby providing a detectable signal. The use of a single fluorophore rather than an “acceptor-donorâ€? fluoresecence resonance energy transfer system offers synthesis and performance advantages.

专利号:CN-1680628-A
优先权日:2005-01-28
标 题:Electrochemical synthesis of biphenyl

专利号:US-11453670-B2
优先权日:2018-06-11
标 题:Substituted heterocycle fused gamma-carbolines synthesis
发明人：LI PENG; ZHANG QIANG
权利人:INTRA CELLULAR THERAPIES INC
摘要:The present invention provides improved methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.