CAS: 2274-42-2; 2-(Methylsulfonyl)Acetonitrile

相似化合物

2516-97-4 13654-62-1 66913-97-1

上下游产品

methylthioacetonitrile sodium methansulfinate chloroacetonitrile2-Methylsulfonylmethylen-thiazolidon-(4) 3-(dimethylamino)-2-(methylsulfonyl)-2-propenenitrile 3-ethoxy-2-methylsulfonyl propenenitrile (Z)-2-Methanesulfonyl-5-phenyl-pent-2-enenitrile

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于双氧水,溶剂黄146体系中,化学反应生成甲基磺酰乙腈
参考文献:Huenig; Boes,Justus Liebigs Annalen Der Chemie,1953,Vol. 579,P. 28,42,43
标题:Huenig; Boes,Justus Liebigs Annalen Der Chemie,1953,Vol. 579,P. 28,42,43

专利信息

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:RU-2035452-C1
优先权日:1985-12-20
标 题 :Method of n-phenylpyrazole synthesis

专利号:CN-110183379-B
优先权日:2019-06-22
标 题 :Synthesis method and application of copper-catalyzed one-pot method for preparing C-4-sulfonyl substituted isoquinolone compounds