CAS: 33208-99-0; H-Ala-Nh2.Hcl

相似化合物

7324-05-2 71810-97-4 80222-96-4

上下游产品

CAS号2491-20-5 L-丙氨酸甲酯盐酸盐 | CAS号78981-25-6 N-B°C-D-丙氨酰胺 | CAS号15967-72-3 (2S)-propane-1,... | CAS号7324-05-2 L-丙氨酰胺 | CAS号133865-89-1 沙芬酰胺 | CAS号174756-44-6 沙芬酰胺对映异构体 | CAS号1142-20-7 |N|-苄氧羰基-L-丙氨酸 | CAS号50444-54-7 benzyl N-[1-[(1... | CAS号65118-54-9 Z-Phe-Ala-NH2

L-丙氨酸甲酯盐酸盐置于氨,盐酸体系中,用 水 作为反应溶剂,化学反应 20.0H,以85 G的收率获得产物l-丙氨酰胺盐酸盐
参考文献:一种l-丙氨酰胺盐酸盐的制备方法
标题:一种l-丙氨酰胺盐酸盐的制备方法
摘要:本发明涉及一种l‑丙氨酰胺盐酸盐的制备方法,具体步骤包括:A.将l‑丙氨酸溶于甲醇中,加入适量的氯化物催化剂进行酯化反应,B.酯化后的产物通入氨气进行氨解反应,C.氨解后的反应液真空升温除氨,然后过滤掉氯化铵,D.过滤后的反应液加酸调整ph值,然后加入适量的酮,析出晶体即l‑丙氨酰胺盐酸盐.本发明的l‑丙氨酰胺盐酸盐的制备方法路线简洁,成本较低,适于大批量生产.

专利信息

专利号:US-11111208-B2
优先权日:2019-06-17
标题:Process for the preparation of safinamide mesylate intermediate
发明人：KOVI RAVISHANKER; KANNAPPAN JAYARAMAN; PATEL RAJESH A; PATEL DAXESHKUMAR PRAKASHBHAI
权利人:RK Pharma Solutions LLC
摘要:The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

专利号:US-7470795-B2
优先权日:2004-07-27
标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
发明人：WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA
权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT
摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

专利号:US-6576454-B2
优先权日:1998-01-23
标 题:Modified enzymes and their use for peptide synthesis
发明人：JONES J BRYAN
权利人:UNIV TORONTO
摘要:The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified by replacing thiol hydrogen in the cysteine residue with a thiol side chain to form a modified enzyme, wherein the modified enzyme has high esterase and low amidase activity. Also, a method of producing the modified enzymes is provided. The present invention also relates to a method for using the modified enzymes in peptide synthesis.

专利号:WO-2017018835-A1
优先权日:2015-07-30
标题 :Method of preparing tdm-621
发明人：CHOI JONG YUN; LEE YEON GUN; JANG WOO YOUNG; YOON HEE KYOON; KIM SEUNG WOO
权利人:DAE WOONG PHARMA
摘要:Disclosed is a method of preparing TDM-621. According to the present invention, conventional problems of a solid-phase synthesis method can be addressed, and thus, high-purity and high-yield TDM-621 can be prepared in a relatively simple method. Therefore, a novel method of preparing TDM-621 according to the present invention is suitable and advantageous in commercially, massively producing TDM-621.

专利号:US-2009088571-A1
优先权日:2004-07-27
标题 :Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

专利号:US-2006025447-A1
优先权日:2004-07-27
标题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides