CAS: 393-36-2; 4-Bromo-3-(Trifluoromethyl)Aniline

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CAS号98-16-8 间三氟甲苯胺 | CAS号367-67-9 2-溴-5-硝基三氟甲苯 | CAS号392-83-6 邻溴三氟甲苯 | CAS号320-49-0 3-三氟甲基-4-溴苯酚 | CAS号344-65-0 2-溴-5-氯三氟甲苯 | CAS号41513-05-7 4′-溴-3′-(三氟甲基)乙酰苯胺 | CAS号1735-53-1 3-三氟甲基-4-溴苯腈 | CAS号392-83-6 邻溴三氟甲苯 | CAS号51332-24-2 4-溴-N,N-二甲基-3-三氟甲基苯胺 | CAS号267242-09-1 4-氰基-2-三氟甲基苯甲酸 | CAS号654-70-6 4-氨基-2-三氟甲基苯甲腈 | CAS号683241-86-3 4-溴-2-硝基-5-三氟甲基苯胺 | CAS号65934-74-9 4-甲基-3-(三氟甲基)苯胺

邻溴三氟甲苯置于哌嗪,硫酸,氢气,硝酸体系中,用 甲醇 用作溶剂,50.0~90.0 °C,1.0 Mpa 条件下,反应生成3-三氟甲基-4-溴苯胺
参考文献:一种2-溴-5-氟三氟甲苯的合成方法
标题:一种2-溴-5-氟三氟甲苯的合成方法
摘要:一种2‑溴‑5‑氟三氟甲苯的合成方法,属于化学合成领域.以邻三氟甲基苯胺为起始原料,具体步骤包括:(1)桑德迈尔溴化反应;(2)硝化反应;(3)催化加氢还原反应;(4)重氮化氟代反应.上述一种2‑溴‑5‑氟三氟甲苯的合成方法,以邻三氟甲基苯胺为原料,经桑德迈尔反应溴代,硝化,加氢还原,最后经重氮化氟代合成了2‑溴‑5‑氟三氟甲苯,纯度达到99.0%以上,杂质种类少,产品质量和性能稳定.

专利信息

专利号:US-6235871-B1
优先权日:1997-12-03
标题:Synthesis of oligoarylamines, and uses and reagents related thereto
发明人：SINGER ROBERT A; SADIGHI JOSEPH P; BUCHWALD STEPHEN L; MACKEWITZ THOMAS
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common organic solvents, and are easily converted to the deprotected oligoanilines. The method allows the preparation of oligoanilines of even or odd chain lengths, and the incorporation of a variety of functional groups into the oligomers. Polyanilines of low polydispersity can also be prepared by this method.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-7615300-B2
优先权日:2005-08-30
标 题 :Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology
发明人：BAE CHULSUNG
权利人:REGENTS UNIVERSITY AND COMMUNI
摘要:New thermally and chemically stable sulfonic acid-containing polymers are synthesized via post-sulfonation of aromatic polymers. These new polymers provide unique benefits to proton exchange membrane fuel cell technology (“PEMFCâ€?). As a sulfonic acid moiety can be easily installed into an aromatic ring via electrophilic sulfonation, even in the presence of an electron-withdrawing substituent such as —F, rigid polymers consisting of aromatic rings at either the side chain or main chain can be prepared with a wide range of substituents and flexibility in properties. Novel synthetic procedures are provided for synthesis of the polymers.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9428500-B2
优先权日:2012-05-11
标 题 :Alpha-carbolines for the treatment of cancer
发明人：GAMBACORTI-PASSERINI CARLO; MOLOGNI LUCA; SCAPOZZA LEONARDO; BISSON WILLIAM; AHMED SHAHEEN; GOEKJIAN PETER; TARDY SÉBASTIEN; ORSATO ALEXANDRE; GUEYRARD DAVID; BENOIT JOSEPH
权利人:UNIVERSITA' DEGLI STUDI DI MILANO—BICOCCA; UNIV GENEVE; UNIVERSITÉ CLAUDE BERNARD—LYON 1; UNIV DEGLI STUDI DI MILANO—BICOCCA; UNIV GENEVE; UNIV CLAUDE BERNARD—LYON
摘要:The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards their synthesis. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.