CAS: 3984-34-7; 3-(4-Chlorobenzoyl)Propionic Acid

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CAS号29582-39-6 反-3-(4-氯苯甲酰)丙烯酸 | CAS号108-30-5 丁二酸酐 | CAS号108-90-7 氯苯 | CAS号292638-85-8 丙烯酸甲酯 | CAS号33599-26-7 2-(4-氯苯基)-2-吗啉乙腈 | CAS号40394-87-4 4-(4-氯苯基)-4-氧代丁腈 | CAS号7148-01-8 4-(4-氯苯基)-4-氧代丁酸甲酯 | CAS号51833-36-4 chloro(p-chloro... | CAS号1079-73-8 2,3,4,5-四氢-6(4-... | CAS号58059-29-3 3-氯-6-(4-氯苯基)哒嗪 | CAS号4619-18-5 4-(4-氯苯基)丁酸 | CAS号18410-18-9 5-(4-chlorophen... | CAS号18338-90-4 2(3H)-Furanone,... | CAS号2166-13-4 6-(4-氯苯基)-2H-哒嗪-3-酮 | CAS号2166-01-0 6-(4-chlorophen... | CAS号20637-04-1 4-氯苯丁酸甲酯 | CAS号141-82-2 丙二酸 | CAS号74-11-3 对氯苯甲酸

4-(4-氯苯基)-4-氧代丁酸甲酯 反应生成3-(4-氯苯甲酰)丙酸
参考文献:The Use Of Organocadmium Reagents For The Preparation Of Substituted β-Aroylpropionic Acids
标题:The Use Of Organocadmium Reagents For The Preparation Of Substituted β-Aroylpropionic Acids
摘要:
Doi:10.1021/jo01150A010

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6132953-A
优先权日:1996-07-02
标 题 :Combinatorial synthesis on soluble polyvalent supports having a discrete architecture
发明人：CHAPMAN KEVIN T; HUTCHINS STEVEN M; KIM RONALD M; MANNA MAHUA
权利人:MERCK & CO INC
摘要:The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

专利号:US-11884628-B2
优先权日:2019-05-16
标题 :Method for synthesizing lactam derivatives without use of catalyst
发明人：YANG SONG; LI HU; WU HONGGUO
权利人:UNIV GUIZHOU
摘要:Disclosed is a simple synthesis method of lactam derivatives, comprising: with formamide functioning as both an amine source and a hydrogen source (hydrolyzed to produce formic acid), carrying out a cycloamination reaction on a raw material keto acid in the absence of a solvent or a catalyst to simply synthesize a lactam derivative. Compared with previous reports, the present disclosure has the following advantages: the time required for the reaction is greatly shortened, the selectivity is remarkably improved, a conversion rate of a keto acid derivative is greater than 99%, and the yield of the lactam derivative can reach 70% to 94%.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK