CAS: 505-48-6; Octanedioic Acid

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629-41-4 1732-09-8 2050-23-9

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CAS号502-49-8 环辛酮 | CAS号931-88-4 环辛烯 | CAS号65111-06-0 °Ct-4-ynedioic acid | CAS号629-40-3 辛二腈 | CAS号27607-33-6 顺-1,2-环辛二醇 | CAS号42565-22-0 (1R,2R)-1,2-Cyc... | CAS号696-71-9 环辛醇 | CAS号5698-50-0 2-°Ctenedioic acid | CAS号292-64-8 环辛烷 | CAS号10521-06-9 氧杂蒽酮-2,9-二酮 | CAS号3946-32-5 辛二酸单甲酯 | CAS号1732-09-8 辛二酸二甲酯 | CAS号38937-66-5 软木肟酸 | CAS号149647-86-9 8-(hydroxyamino... | CAS号41624-92-4 8-氯-8-氧代辛酸甲酯 | CAS号20920-03-0 1-羟基-环庚羧酸 | CAS号19812-63-6 十四烷二酸二乙酯 | CAS号502-42-1 环庚酮 | CAS号111-14-8 庚酸

环辛烷置于n-羟基邻苯二甲酰亚胺,硝酸,三氟乙酸体系中,20.0 °C,101.33 Kpa 条件下,反应 18.0H,以30%的收率获得产物辛二酸
参考文献:在常温常压下有机合成催化环己烷直接氧化合成己二酸
标题:在常温常压下有机合成催化环己烷直接氧化合成己二酸
摘要:据报道,由环己烷生产己二酸的直接无金属方法.在hno 3 / Tfa存在下使用n-羟基邻苯二甲酰亚胺(nhpi)作为催化剂能够通过简单的方法在环境温度和压力下将环己烷直接氧化以产生己二酸.该反应通过将环己烷最初氧化为环己酮肟和环己酮,然后将这些中间体第二次氧化为己二酸而进行.nhpi在两个氧化步骤中都起着至关重要的作用,以实现己二酸的高收率和选择性.
DOI:10.1021/acs.Oprd.8B00196

专利信息

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:US-12263464-B2
优先权日:2018-03-14
标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof
发明人：PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU
权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD
摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.

专利号:US-4835247-A
优先权日:1988-08-08
标 题:Process for the synthesis of a copolyester adhesive resin
发明人：WILSON JOHN R; ROUSEK MARIAN M; MASSEY FRED L
权利人:GOODYEAR TIRE & RUBBER
摘要:Isophthalic acid is commonly utilized as a comonomer in the preparation of copolyester resins which are utilized as solution adhesives. Unfortunately, solutions of such resins frequently become hazy due to the presence of cyclic oligomers. This invention is based upon the unexpected discovery that the presence of protonic acids during the synthesis of the copolyester resins containing isophthalic acid utilizing conventional metallic catalysts results in solutions of the resins in organic solvents being virtually haze free. The subject invention more specifically reveals a process for synthesizing a polyethylene terephthalate/isophthalate/azelate copolyester resin which is particularly useful as a solution adhesive resin, comprising reacting ethylene glycol with a diacid component which is comprised of (a) from about 25 to about 45 mole percent terephthalic acid, (b) from about 10 to about 30 to about 55 mole percent azelaic acid based upon the diacid component; in the presence of at least one metallic catalyst selected from the group consisting of antimony compounds, titanium compounds; manganese compounds, and germanium compounds and in the presence of at least one protonic acid having a pKa of less than about 2.5; wherein the amount of metallic catalyst present is within the rang eof about 130 ppm to about 1500 ppm and wherein the amount of protonic acid present is within the range of about 50 ppm to about 500 ppm, with said amounts being based upon the weight of the copolyester resin produced.

专利号:US-4921929-A
优先权日:1988-08-08
标 题:Process for the synthesis of a copolyester adhesive resin
发明人：WILSON JOHN R; ROUSEK MARIAN M; MASSEY FRED L
权利人:GOODYEAR TIRE & RUBBER
摘要:Isophthalic acid is commonly utilized as a comonomer in the preparation of copolyester resins which are utilized as solution adhesives. Unfortunately, solutions of such resins frequently become hazy due to the presence of cyclic oligomers. This invention is based upon the unexpected discovery that the presence of protonic acids during the synthesis of the copolyester resins containing isophthalic acid utilizing conventional metallic catalysts results in solutions of the resins in organic solvents being virtually haze free. The subject invention more specifically reveals a process for synthesizing a polyethylene terephthalate/isophthalate/azelate copolyester resin which is particularly useful as a solution adhesive resin, comprising reacting ethylene glycol with a diacid component which is comprised of (a) from about 25 to about 45 mole percent terephthalic acid, (b) from about 10 to about 30 mole percent isophthalic acid, and (c) from about 30 to about 55 mole percent azelaic acid based upon the diacid component; in the presence of at least one metallic catalyst selected from the group consisting of antimony compounds, titanium compounds; manganese compounds, and germanium compounds and in the presence of at least one protonic acid having a pKa of less than about 2.5; wherein the amount of metallic catalyst present is within the range of about 130 ppm to about 1500 ppm and wherein the amount of protonic acid present is within the range of about 50 ppm to about 500 ppm, with said amounts being based upon the weight of the copolyester resin produced.

专利号:WO-2012088402-A1
优先权日:2010-12-22
标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
发明人：BOHN LAURA M; MICALIZIO GLENN C
权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

专利号:US-5262176-A
优先权日:1986-07-03
标题:Synthesis of polysaccharide covered superparamagnetic oxide colloids
发明人：PALMACCI STEPHEN; JOSEPHSON LEE
权利人:ADVANCED MAGNETICS INC
摘要:In a method for the synthesis of a colloid including a superparamagnetic metal oxide coated with a polymer, an acidic solution of a metal salt and a polymer may be cooled, and then neutralized by the controlled addition of a cool solution of a base, and may then be converted, by the application of heat, to a homogenous superparamagnetic metal oxide colloid. According to a preferred embodiment, the polymer may be a polysaccharide. In a further embodiment of the invention, the polysaccharide may be dextran and the metal salt may be ferrous and ferric salts, which produces, according to the methods of the invention, a superparamagnetic iron oxide colloid with an extended plasma half-life.