专利号:WO-2020253244-A1 优先权日:2019-06-20 标 题 :Process for catalytic synthesis of lactide 发明人:JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD 摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.
专利号:US-9783549-B2 优先权日:2013-11-04 标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B 发明人:FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
专利号:US-9040742-B2 优先权日:2011-12-27 标题:Catalytic synthesis of vitamin A intermediate 发明人:BONRATH WERNER; WUESTENBERG BETTINA; NETSCHER THOMAS; SCHUETZ JAN 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a process of production of a compound, which is useful as an intermediate (building block) in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.
专利号:US-7951961-B2 优先权日:2006-07-07 标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof 发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT 权利人:PIRAMAL LIFE SCIENCES LTD 摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.
专利号:US-6603070-B2 优先权日:2000-07-21 标题 :Convergent synthesis of multiporphyrin light-harvesting rods 发明人:LINDSEY JONATHAN S; LOEWE ROBERT S 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.
专利号:US-2024327370-A1 优先权日:2021-07-01 标题:Process for the biobased synthesis of schweinfurthins g, k and r 发明人:ROUSSI FANNY; LITAUDON MARC; DESRAT SANDY; JEZEQUEL GWENAËLLE; RAMPAL CÉLINE; PHAM VAN CUONG; DOAN THI MAI HUONG 权利人:CENTRE NAT RECH SCIENT; VAST VIETNAM ACADEMY OF SCIENCE AND TECH 摘要:The present invention relates to a process for preparing at least one schweinfurthin chosen from schweinfurthin G of formula (SW-G), schweinfurthin K of formula (SW-K) and schweinfurthin R of formula (SW-R), characterized in that it comprises a step of using mappain of formula (IV).
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合成参考文献
摘要:L539: Wikipedia. Zinc trifluoromethanesulfonate. Last Updated 15 May 2009. http://en.wikipedia.org/wiki/Zinc_trifluoromethanesulfonate