CAS: 55135-66-5; 9-Bromo-9-Phenyl-9H-Fluorene

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CAS号789-24-2 9-苯基-9H-芴 | CAS号506-96-7 乙酰溴 | CAS号25603-67-2 9-苯基-9-芴醇 | CAS号76-84-6 三苯基甲醇 | CAS号7726-95-6 溴素 | CAS号18554-43-3 9-phenylfluoren... | CAS号179990-59-1 (4R, 2S)-4-Hydr... | CAS号25022-99-5 9H-Fluorene,9-c... | CAS号27608-12-4 1-(9-phenylfluo... | CAS号160882-76-8 (2S)-4-Oxo-1-(9... | CAS号105-36-2 溴乙酸乙酯 | CAS号25603-67-2 9-苯基-9-芴醇 | CAS号76756-37-1 9-(9H-fluoren-9... | CAS号789-24-2 9-苯基-9H-芴

9-苯基芴置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 作为反应溶剂,化学反应 1.0H,以96%的收率获得产物9-溴-9-苯基芴
参考文献:烷基取代基对胡椒基酰胺异构体平衡的影响:合成对映纯6烷基哌酸及其n-乙酰基n'-甲基酰胺的构象分析的有效方法.
标题:烷基取代基对胡椒基酰胺异构体平衡的影响:合成对映纯6烷基哌酸及其n-乙酰基n'-甲基酰胺的构象分析的有效方法.
摘要:通过选择性地将氢化物还原为相应的天冬氨酸的方法,以五个步骤合成了对映体纯的6-烷基胡椒酸盐酸盐1A-E,总产率为15-59%,由α-叔丁基β-甲基n-(phf)天门冬氨酸(3)合成β-醛2,与各种甲基烷基酮的烯醇式缩醛醇缩合,以及非对映选择性分子内还原胺化.然后,通过合成n-乙酰基n'-甲基哌嗪酰胺(16)及其(2S,6R)-,探索了6位取代基对酰胺n端异构化为哌酸酯的平衡和能垒的影响. 6-叔丁基哌嗪酰胺对应物17,并通过质子NMR光谱和聚结实验对它们进行构象分析.叔丁基取代基的存在增加了酰胺顺式异构体的数量,并降低了在水中胡椒基酰胺异构化的障碍.与我们之前对n-乙酰基-5-叔丁基脯氨酸n'-甲基酰胺的检测结果相比(beausoleil,E.; Lubell,Wdj Am.chem.soc.1996,118,12902),笨重的结果6相对于相应的脯氨酸酰胺,在胡椒酸酯系列中,乙酰胺几何形
DOI:10.1021/jo982181H

专利信息

专利号:BR-112015000232-B1
优先权日:2012-07-13
标 题:METHOD FOR SYNTHESIS OF GAMMA, DELTA-DIHYDROXY-ISOLEUCINE, COMPOUND, KIT AND METHOD TO SYNTHESIS AN AMATOXIN

专利号:US-6166229-A
优先权日:1999-02-26
标 题 :N-trityl and N-phenylfluorenyl carboxyanhydrides of amino acids
发明人：RAPOPORT HENRY; SIM TAE BO
权利人:UNIV CALIFORNIA
摘要:Amino acids are derivatized for use in peptide synthesis by conversion to N-carboxyanhydrides that are N-protected by either a trityl or a phenylfluorenyl group.

专利号:WO-9221675-A1
优先权日:1991-06-03
标题:Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:US-9676702-B2
优先权日:2012-07-13
标题:Methods for synthesizing amatoxin building block and amatoxins
发明人：LUTZ CHRISTIAN; MUELLER CHRISTOPH; SIMON WERNER
权利人:HEIDELBERG PHARMA GMBH
摘要:The invention relates to novel methods for synthesizing a synthon for γ,δ-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

专利号:CN-1065238-C
优先权日:1993-01-29
标题 :Intermediate compounds suitable for the synthesis of modified oligodeoxynucleotides

专利号:EP-0643710-A1
优先权日:1991-06-03
标 题 :Synthesis of optically active lactones from l-aspartic acid and intermediates thereof