CAS: 610-94-6; Methyl 2-Bromobenzoate

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CAS号67-56-1 甲醇 | CAS号88-65-3 邻溴苯甲酸 | CAS号75-91-2 叔丁基过氧化氢 | CAS号18982-54-2 2-溴苄醇 | CAS号6630-33-7 2-溴苯甲醛 | CAS号201230-82-2 carbon monoxide | CAS号583-53-9 1,2-二溴苯 | CAS号586-76-5 对溴苯甲酸 | CAS号107-06-2 1,2-二氯乙烷 | CAS号95-46-5 2-溴甲苯 | CAS号1077-79-8 2-乙酰基苯甲酸甲酯 | CAS号107793-07-7 METHYL 2-((TRIM... | CAS号4526-07-2 1,4-双(三甲硅基)-1,3-丁二炔 | CAS号106047-16-9 methyl 2-pyridi... | CAS号331942-47-3 2-(2-呋喃基)苯甲酸 | CAS号607-19-2 3-甲基喹唑啉-2,4(1h,... | CAS号53882-80-7 2-溴苯甲酰乙腈 | CAS号6072-49-7 2-噻吩基苯甲酸 | CAS号39732-01-9 2-呋喃-2-苯甲酸甲酯 | CAS号374538-03-1 2-(甲氧基羰基)苯硼酸

苯甲酸甲酯置于n-溴代丁二酰亚胺(Nbs),Silver Hexafluoroantimonate,三氟甲磺酸,Nickel Diacetate体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 12.0H,以76%的收率获得产物邻溴苯甲酸甲酯
参考文献:缺电子芳烃的镍催化区域选择性c-h卤化†
标题:缺电子芳烃的镍催化区域选择性c-h卤化†
摘要:开发了一种简单的ni(II)催化的一般策略,用于用易获得的卤化试剂n-卤代琥珀酰亚胺(nxs; X = Br,Cl和i)对电子缺陷型芳烃进行邻卤代化.该转化是高度区域选择性的,并且观测到宽的底物范围和官能团耐受性.该发现对于酰胺,苯甲酸酯和其他具有引导基团的物质的选择性卤化可能具有重要意义.还介绍了机械研究.
DOI:10.1039/c8Nj06023A

专利信息

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-10793551-B2
优先权日:2017-10-19
标 题:Benzimidazole-indole inhibitors of Mnk1 and Mnk2
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; XIANG ALAN X
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I or Formula II, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , Y 1 , Y 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are as defined in the specification. The inventive Formula I and Formula II compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-7645754-B2
优先权日:2001-12-20
标题 :Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use
发明人：CASTELHANO ARLINDO; MCKIBBEN BRYAN; STEINIG ARNO
权利人:OSI PHARM INC
摘要:The subject invention provides compounds having the structure: n n n n n n n n n n n n wherein,n R 1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O) R a ; R 2 is hydrogen or a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O)R a , or R 1 , R 2 and N together form a substituted piperazine, substituted azetidine ring, or a pyrrolidine ring substituted with —(CH 2 ) 2 OH or —CH 2 C(â•?O)OH; R 3 is a substituted or unsubstituted phenyl or a 5-6 membered heteroaryl ring, wherein the substituent is halogen, hydroxyl, cyano, (C 1 -C 15 )alkyl, (C 1 -C 15 )alkoxy, or —NR a R b ; R 4 is hydrogen or substituted or unsubstituted (C 1 -C 15 )alkyl; R 5 is —(CH 2 ) m OR 6 , —CHNOR 7 , —C(â•?O)NR 8 R 9 , —(CH 2 ) m C(â•?O)OR 10 , —(CH 2 ) k C(â•?O)NR 11 R 12 ;n wherein R 6 is a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or 4-8 membered heterocyclic ring; R 7 is hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl; R 8 and R 9 are each independently hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl, (C 1 -C 30 )alkylamino, (C 1 -C 30 )alkoxy, or a saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic ring, or R 8 , N, and R 9 together form a substituted or unsubstituted 4-8 membered heterocyclic ring; R 10 is hydrogen or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or heterocyclic ring; R 11 , N and R 12 together form a 4-8 membered heterocyclic ring; R a and R b are each independently hydrogen or alkyl; m is 0, 1, 2 or 3; and k is 1, 2 or 3,n nor a specific enantiomer thereof, or a specific tautomer thereof, or a pharmaceutically acceptable salt thereof, and a method for treating a disease associated with the A 2b adenosine receptor in a sbject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compounds of the invention.

专利号:WO-2008035086-A2
优先权日:2006-09-22
标题:Synthesis of leukotriene compounds

专利号:CN-118724753-A
优先权日:2024-06-18
标题:Method for promoting synthesis of hydroxamic acid by using metal salt

专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer